Studies on Cross-linking of succinic acid with chitosan/collagen
The present study summarizes the cross-linking property of succinic acid with chitosan /collagen. In detail, the chemistry behind the cross-linking and the improvement in mechanical and thermal properties of the cross-linked material were discussed with suitable instruments and bioinformatics tools....
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Associação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímeros (ABPol)
2013-01-01
|
Series: | Materials Research |
Subjects: | |
Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392013005000059 |
id |
doaj-bd5a97bd6c8a4133b71c34959eb9257c |
---|---|
record_format |
Article |
spelling |
doaj-bd5a97bd6c8a4133b71c34959eb9257c2020-11-24T21:33:19ZengAssociação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímeros (ABPol)Materials Research1516-14392013-01-01ahead0Studies on Cross-linking of succinic acid with chitosan/collagenTapas MitraG. SailakshmiA. GnanamaniA. B. MandalThe present study summarizes the cross-linking property of succinic acid with chitosan /collagen. In detail, the chemistry behind the cross-linking and the improvement in mechanical and thermal properties of the cross-linked material were discussed with suitable instruments and bioinformatics tools. The concentration of succinic acid with reference to the chosen polymers was optimized. A 3D scaffold prepared using an optimized concentration of succinic acid (0.2% (w/v)) with chitosan (1.0% (w/v)) and similarly with collagen (0.5% (w/v)), was subjected to surface morphology, FT-IR analysis, tensile strength assessment, thermal stability and biocompatibility. Results revealed, cross-linking with succinic acid impart appreciable mechanical strength to the scaffold material. In silico analysis suggested the prevalence of non-covalent interactions, which played a crucial role in improving the mechanical and thermal properties of the cross-linked scaffold. The resultant 3D scaffold may find application as wound dressing material, as an implant in clinical applications and as a tissue engineering material.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392013005000059succinic acidchitosancollagen3D scaffold |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tapas Mitra G. Sailakshmi A. Gnanamani A. B. Mandal |
spellingShingle |
Tapas Mitra G. Sailakshmi A. Gnanamani A. B. Mandal Studies on Cross-linking of succinic acid with chitosan/collagen Materials Research succinic acid chitosan collagen 3D scaffold |
author_facet |
Tapas Mitra G. Sailakshmi A. Gnanamani A. B. Mandal |
author_sort |
Tapas Mitra |
title |
Studies on Cross-linking of succinic acid with chitosan/collagen |
title_short |
Studies on Cross-linking of succinic acid with chitosan/collagen |
title_full |
Studies on Cross-linking of succinic acid with chitosan/collagen |
title_fullStr |
Studies on Cross-linking of succinic acid with chitosan/collagen |
title_full_unstemmed |
Studies on Cross-linking of succinic acid with chitosan/collagen |
title_sort |
studies on cross-linking of succinic acid with chitosan/collagen |
publisher |
Associação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímeros (ABPol) |
series |
Materials Research |
issn |
1516-1439 |
publishDate |
2013-01-01 |
description |
The present study summarizes the cross-linking property of succinic acid with chitosan /collagen. In detail, the chemistry behind the cross-linking and the improvement in mechanical and thermal properties of the cross-linked material were discussed with suitable instruments and bioinformatics tools. The concentration of succinic acid with reference to the chosen polymers was optimized. A 3D scaffold prepared using an optimized concentration of succinic acid (0.2% (w/v)) with chitosan (1.0% (w/v)) and similarly with collagen (0.5% (w/v)), was subjected to surface morphology, FT-IR analysis, tensile strength assessment, thermal stability and biocompatibility. Results revealed, cross-linking with succinic acid impart appreciable mechanical strength to the scaffold material. In silico analysis suggested the prevalence of non-covalent interactions, which played a crucial role in improving the mechanical and thermal properties of the cross-linked scaffold. The resultant 3D scaffold may find application as wound dressing material, as an implant in clinical applications and as a tissue engineering material. |
topic |
succinic acid chitosan collagen 3D scaffold |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392013005000059 |
work_keys_str_mv |
AT tapasmitra studiesoncrosslinkingofsuccinicacidwithchitosancollagen AT gsailakshmi studiesoncrosslinkingofsuccinicacidwithchitosancollagen AT agnanamani studiesoncrosslinkingofsuccinicacidwithchitosancollagen AT abmandal studiesoncrosslinkingofsuccinicacidwithchitosancollagen |
_version_ |
1725953753430884352 |