Effects of Combined Intralesional 5-Fluorouracil and Topical Silicone in Prevention of Keloids: A Double Blind Randomized Clinical Trial Study
Keloids are aesthetically disfiguring and severely disabling. The optimal treatment remains undefined. This clinical study, evaluate the efficacy and side effects of combined topical silicone and 5-Fluorouracil on the prevention of keloids. In this double blind randomized clinical trial, fifty patie...
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Tehran University of Medical Sciences
2011-03-01
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doaj-bd5ab2ccb345491795f68e987814487c2020-11-25T03:23:25ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942011-03-01493Effects of Combined Intralesional 5-Fluorouracil and Topical Silicone in Prevention of Keloids: A Double Blind Randomized Clinical Trial StudyEbrahim Hatamipour0Saadat Mehrabi1Mohsen Hatamipour2Hamid Reza Ghafarian Shirazi3Department of Surgery and Burn, Yasuj University of Medical Sciences, Yasuj, Iran.Department of Surgery and Burn, Yasuj University of Medical Sciences, Yasuj, Iran.Department of Surgery and Burn, Yasuj University of Medical Sciences, Yasuj, Iran.Department of Social Medicine, Faculty of Medicine; Yasuj University of Medical Sciences, Yasuj, Iran. AND Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.Keloids are aesthetically disfiguring and severely disabling. The optimal treatment remains undefined. This clinical study, evaluate the efficacy and side effects of combined topical silicone and 5-Fluorouracil on the prevention of keloids. In this double blind randomized clinical trial, fifty patients with keloids were randomly allocated in two groups. The control group were treated by perilesional surgical excision of keloids combined with topical silicone and the trial group were treated with adjuvant treatment of intralesional 5-Fluorouracil. All patients were examined and assessment was done by an independent observer. the data collected were analyzed by SPSS statistical software with using tables and χ square tests. 75% of the cases in the trial group were keloid free 21% have keloid partially improvement and 4% have keloid recurrence, compared to patients in the control group respectively: 43%, 35% and 22%, findings suggest that efficacy of 5-Fluorouracil combined with topical silicone used for the prevention of keloid is comparable to other modality. The lack of any serious side effects and the evidence of recurrence at one year of follow-up make this an effective tool for the prevention of keloids. https://acta.tums.ac.ir/index.php/acta/article/view/3709KeloidSiliconesAdministrationtopicalFluorouracil |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ebrahim Hatamipour Saadat Mehrabi Mohsen Hatamipour Hamid Reza Ghafarian Shirazi |
spellingShingle |
Ebrahim Hatamipour Saadat Mehrabi Mohsen Hatamipour Hamid Reza Ghafarian Shirazi Effects of Combined Intralesional 5-Fluorouracil and Topical Silicone in Prevention of Keloids: A Double Blind Randomized Clinical Trial Study Acta Medica Iranica Keloid Silicones Administration topical Fluorouracil |
author_facet |
Ebrahim Hatamipour Saadat Mehrabi Mohsen Hatamipour Hamid Reza Ghafarian Shirazi |
author_sort |
Ebrahim Hatamipour |
title |
Effects of Combined Intralesional 5-Fluorouracil and Topical Silicone in Prevention of Keloids: A Double Blind Randomized Clinical Trial Study |
title_short |
Effects of Combined Intralesional 5-Fluorouracil and Topical Silicone in Prevention of Keloids: A Double Blind Randomized Clinical Trial Study |
title_full |
Effects of Combined Intralesional 5-Fluorouracil and Topical Silicone in Prevention of Keloids: A Double Blind Randomized Clinical Trial Study |
title_fullStr |
Effects of Combined Intralesional 5-Fluorouracil and Topical Silicone in Prevention of Keloids: A Double Blind Randomized Clinical Trial Study |
title_full_unstemmed |
Effects of Combined Intralesional 5-Fluorouracil and Topical Silicone in Prevention of Keloids: A Double Blind Randomized Clinical Trial Study |
title_sort |
effects of combined intralesional 5-fluorouracil and topical silicone in prevention of keloids: a double blind randomized clinical trial study |
publisher |
Tehran University of Medical Sciences |
series |
Acta Medica Iranica |
issn |
0044-6025 1735-9694 |
publishDate |
2011-03-01 |
description |
Keloids are aesthetically disfiguring and severely disabling. The optimal treatment remains undefined. This clinical study, evaluate the efficacy and side effects of combined topical silicone and 5-Fluorouracil on the prevention of keloids. In this double blind randomized clinical trial, fifty patients with keloids were randomly allocated in two groups. The control group were treated by perilesional surgical excision of keloids combined with topical silicone and the trial group were treated with adjuvant treatment of intralesional 5-Fluorouracil. All patients were examined and assessment was done by an independent observer. the data collected were analyzed by SPSS statistical software with using tables and χ square tests. 75% of the cases in the trial group were keloid free 21% have keloid partially improvement and 4% have keloid recurrence, compared to patients in the control group respectively: 43%, 35% and 22%, findings suggest that efficacy of 5-Fluorouracil combined with topical silicone used for the prevention of keloid is comparable to other modality. The lack of any serious side effects and the evidence of recurrence at one year of follow-up make this an effective tool for the prevention of keloids.
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topic |
Keloid Silicones Administration topical Fluorouracil |
url |
https://acta.tums.ac.ir/index.php/acta/article/view/3709 |
work_keys_str_mv |
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