Oxaliplatin Causes Transient Changes in TRPM8 Channel Activity

Oxaliplatin Causes Transient Changes in TRPM8 Channel Activity

Oxaliplatin is a third-generation platinum-based anticancer drug that is widely used as first-line treatment for colorectal carcinoma. Patients treated with oxaliplatin develop an acute peripheral pain several hours after treatment, mostly characterized by cold allodynia as well as a long-term chron...

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Bibliographic Details
Main Authors: Vittoria Rimola, Tabea Osthues, Vanessa Königs, Gerd Geißlinger, Marco Sisignano
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
oxaliplatin
TRPM8
desensitization
acute pain
neuropathic pain
Online Access:https://www.mdpi.com/1422-0067/22/9/4962

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