Overview of Experimental and Clinical Findings regarding the Neuroprotective Effects of Cerebral Ischemic Postconditioning
Research on attenuating the structural and functional deficits observed following ischemia-reperfusion has become increasingly focused on the therapeutic potential of ischemic postconditioning. In recent years, various methods and animal models of ischemic postconditioning have been utilized. The re...
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Series: | BioMed Research International |
Online Access: | http://dx.doi.org/10.1155/2017/6891645 |
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doaj-bd60573a7c7d480e8eb145855f6d03022020-11-25T00:48:04ZengHindawi LimitedBioMed Research International2314-61332314-61412017-01-01201710.1155/2017/68916456891645Overview of Experimental and Clinical Findings regarding the Neuroprotective Effects of Cerebral Ischemic PostconditioningDi Ma0Liangshu Feng1Fang Deng2Jia-Chun Feng3Department of Neurology and Neuroscience Center, the First Hospital of Jilin University, Changchun 130021, ChinaDepartment of Neurology and Neuroscience Center, the First Hospital of Jilin University, Changchun 130021, ChinaDepartment of Neurology and Neuroscience Center, the First Hospital of Jilin University, Changchun 130021, ChinaDepartment of Neurology and Neuroscience Center, the First Hospital of Jilin University, Changchun 130021, ChinaResearch on attenuating the structural and functional deficits observed following ischemia-reperfusion has become increasingly focused on the therapeutic potential of ischemic postconditioning. In recent years, various methods and animal models of ischemic postconditioning have been utilized. The results of these numerous studies have indicated that the mechanisms underlying the neuroprotective effects of ischemic postconditioning may involve reductions in the generation of free radicals and inhibition of calcium overload, as well as the release of endogenous active substances, alterations in membrane channel function, and activation of protein kinases. Here we review the novel discovery, mechanism, key factors, and clinical application of ischemic postconditioning and discuss its implications for future research and problem of clinical practice.http://dx.doi.org/10.1155/2017/6891645 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Di Ma Liangshu Feng Fang Deng Jia-Chun Feng |
spellingShingle |
Di Ma Liangshu Feng Fang Deng Jia-Chun Feng Overview of Experimental and Clinical Findings regarding the Neuroprotective Effects of Cerebral Ischemic Postconditioning BioMed Research International |
author_facet |
Di Ma Liangshu Feng Fang Deng Jia-Chun Feng |
author_sort |
Di Ma |
title |
Overview of Experimental and Clinical Findings regarding the Neuroprotective Effects of Cerebral Ischemic Postconditioning |
title_short |
Overview of Experimental and Clinical Findings regarding the Neuroprotective Effects of Cerebral Ischemic Postconditioning |
title_full |
Overview of Experimental and Clinical Findings regarding the Neuroprotective Effects of Cerebral Ischemic Postconditioning |
title_fullStr |
Overview of Experimental and Clinical Findings regarding the Neuroprotective Effects of Cerebral Ischemic Postconditioning |
title_full_unstemmed |
Overview of Experimental and Clinical Findings regarding the Neuroprotective Effects of Cerebral Ischemic Postconditioning |
title_sort |
overview of experimental and clinical findings regarding the neuroprotective effects of cerebral ischemic postconditioning |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2017-01-01 |
description |
Research on attenuating the structural and functional deficits observed following ischemia-reperfusion has become increasingly focused on the therapeutic potential of ischemic postconditioning. In recent years, various methods and animal models of ischemic postconditioning have been utilized. The results of these numerous studies have indicated that the mechanisms underlying the neuroprotective effects of ischemic postconditioning may involve reductions in the generation of free radicals and inhibition of calcium overload, as well as the release of endogenous active substances, alterations in membrane channel function, and activation of protein kinases. Here we review the novel discovery, mechanism, key factors, and clinical application of ischemic postconditioning and discuss its implications for future research and problem of clinical practice. |
url |
http://dx.doi.org/10.1155/2017/6891645 |
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