T follicular helper and T follicular regulatory cells have different TCR specificity

T follicular helper and T follicular regulatory cells have different TCR specificity

T follicular helper and regulatory cells are generated in the germinal centre; however, whether antigen specificity defines their differential functions is unclear. Here the authors show that T cells with distinct antigen specificity spectra are recruited to the germinal centre to establish these tw...

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Main Authors: Ana Raquel Maceiras, Silvia Cristina Paiva Almeida, Encarnita Mariotti-Ferrandiz, Wahiba Chaara, Fadi Jebbawi, Adrien Six, Shohei Hori, David Klatzmann, Jose Faro, Luis Graca
Format: Article
Language:English
Published: Nature Publishing Group 2017-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15067
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spelling doaj-bd75e21eb1a744808ab34dda848ec1072021-05-11T07:22:44ZengNature Publishing GroupNature Communications2041-17232017-04-018111210.1038/ncomms15067T follicular helper and T follicular regulatory cells have different TCR specificityAna Raquel Maceiras0Silvia Cristina Paiva Almeida1Encarnita Mariotti-Ferrandiz2Wahiba Chaara3Fadi Jebbawi4Adrien Six5Shohei Hori6David Klatzmann7Jose Faro8Luis Graca9Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de LisboaInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de LisboaSorbonne Universités, UPMC Univ Paris 06, UMRS 959, Immunology-Immunopathology-Immunotherapy (i3)Sorbonne Universités, UPMC Univ Paris 06, UMRS 959, Immunology-Immunopathology-Immunotherapy (i3)INSERM, UMRS 959, Immunology-Immunopathology-Immunotherapy (i3)Sorbonne Universités, UPMC Univ Paris 06, UMRS 959, Immunology-Immunopathology-Immunotherapy (i3)Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical SciencesSorbonne Universités, UPMC Univ Paris 06, UMRS 959, Immunology-Immunopathology-Immunotherapy (i3)Instituto Gulbenkian de CiênciaInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de LisboaT follicular helper and regulatory cells are generated in the germinal centre; however, whether antigen specificity defines their differential functions is unclear. Here the authors show that T cells with distinct antigen specificity spectra are recruited to the germinal centre to establish these two populations.https://doi.org/10.1038/ncomms15067
collection DOAJ
language English
format Article
sources DOAJ
author Ana Raquel Maceiras
Silvia Cristina Paiva Almeida
Encarnita Mariotti-Ferrandiz
Wahiba Chaara
Fadi Jebbawi
Adrien Six
Shohei Hori
David Klatzmann
Jose Faro
Luis Graca
spellingShingle Ana Raquel Maceiras
Silvia Cristina Paiva Almeida
Encarnita Mariotti-Ferrandiz
Wahiba Chaara
Fadi Jebbawi
Adrien Six
Shohei Hori
David Klatzmann
Jose Faro
Luis Graca
T follicular helper and T follicular regulatory cells have different TCR specificity
Nature Communications
author_facet Ana Raquel Maceiras
Silvia Cristina Paiva Almeida
Encarnita Mariotti-Ferrandiz
Wahiba Chaara
Fadi Jebbawi
Adrien Six
Shohei Hori
David Klatzmann
Jose Faro
Luis Graca
author_sort Ana Raquel Maceiras
title T follicular helper and T follicular regulatory cells have different TCR specificity
title_short T follicular helper and T follicular regulatory cells have different TCR specificity
title_full T follicular helper and T follicular regulatory cells have different TCR specificity
title_fullStr T follicular helper and T follicular regulatory cells have different TCR specificity
title_full_unstemmed T follicular helper and T follicular regulatory cells have different TCR specificity
title_sort t follicular helper and t follicular regulatory cells have different tcr specificity
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-04-01
description T follicular helper and regulatory cells are generated in the germinal centre; however, whether antigen specificity defines their differential functions is unclear. Here the authors show that T cells with distinct antigen specificity spectra are recruited to the germinal centre to establish these two populations.
url https://doi.org/10.1038/ncomms15067
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