Modulators of MicroRNA Function in the Immune System

Modulators of MicroRNA Function in the Immune System

MicroRNAs (miRNAs) play a key role in fine-tuning host immune homeostasis and responses through the negative regulation of mRNA stability and translation. The pathways regulated by miRNAs are well characterized, but the precise mechanisms that control the miRNA-mediated regulation of gene expression...

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Main Authors: Yunhui Jia, Yuanyuan Wei
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:International Journal of Molecular Sciences
Subjects:
microRNA biogenesis
immune cells
miRNA site
exosome
macrophage
Online Access:https://www.mdpi.com/1422-0067/21/7/2357
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spelling doaj-bd7afcccc95f4a0ca2681a7589b109da2020-11-25T03:08:39ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-03-01212357235710.3390/ijms21072357Modulators of MicroRNA Function in the Immune SystemYunhui Jia0Yuanyuan Wei1Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, ChinaDepartment of Immunology, Shanghai Key laboratory of Bioactive Small Molecules, State Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, ChinaMicroRNAs (miRNAs) play a key role in fine-tuning host immune homeostasis and responses through the negative regulation of mRNA stability and translation. The pathways regulated by miRNAs are well characterized, but the precise mechanisms that control the miRNA-mediated regulation of gene expression during immune cell-development and immune responses to invading pathogens are incompletely understood. Context-specific interactions of miRNAs with other RNA species or proteins may modulate the function of a given miRNA. Dysregulation of miRNA function is associated with various human diseases, such as cardiovascular diseases and cancers. Here, we review the potential modulators of miRNA function in the immune system, including the transcription regulators of miRNA genes, miRNA-processing enzymes, factors affecting miRNA targeting, and intercellular communication.https://www.mdpi.com/1422-0067/21/7/2357microRNA biogenesisimmune cellsmiRNA siteexosomemacrophage
collection DOAJ
language English
format Article
sources DOAJ
author Yunhui Jia
Yuanyuan Wei
spellingShingle Yunhui Jia
Yuanyuan Wei
Modulators of MicroRNA Function in the Immune System
International Journal of Molecular Sciences
microRNA biogenesis
immune cells
miRNA site
exosome
macrophage
author_facet Yunhui Jia
Yuanyuan Wei
author_sort Yunhui Jia
title Modulators of MicroRNA Function in the Immune System
title_short Modulators of MicroRNA Function in the Immune System
title_full Modulators of MicroRNA Function in the Immune System
title_fullStr Modulators of MicroRNA Function in the Immune System
title_full_unstemmed Modulators of MicroRNA Function in the Immune System
title_sort modulators of microrna function in the immune system
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1661-6596
1422-0067
publishDate 2020-03-01
description MicroRNAs (miRNAs) play a key role in fine-tuning host immune homeostasis and responses through the negative regulation of mRNA stability and translation. The pathways regulated by miRNAs are well characterized, but the precise mechanisms that control the miRNA-mediated regulation of gene expression during immune cell-development and immune responses to invading pathogens are incompletely understood. Context-specific interactions of miRNAs with other RNA species or proteins may modulate the function of a given miRNA. Dysregulation of miRNA function is associated with various human diseases, such as cardiovascular diseases and cancers. Here, we review the potential modulators of miRNA function in the immune system, including the transcription regulators of miRNA genes, miRNA-processing enzymes, factors affecting miRNA targeting, and intercellular communication.
topic microRNA biogenesis
immune cells
miRNA site
exosome
macrophage
url https://www.mdpi.com/1422-0067/21/7/2357
work_keys_str_mv AT yunhuijia modulatorsofmicrornafunctionintheimmunesystem
AT yuanyuanwei modulatorsofmicrornafunctionintheimmunesystem
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