Isoniazid Concentration and <i>NAT2</i> Genotype Predict Risk of Systemic Drug Reactions during 3HP for LTBI

Isoniazid Concentration and <i>NAT2</i> Genotype Predict Risk of Systemic Drug Reactions during 3HP for LTBI

Weekly rifapentine and isoniazid therapy (known as 3HP) for latent tuberculosis infection (LTBI) is increasingly used, but systemic drug reactions (SDR) remain a major concern. Methods: We prospectively recruited two LTBI cohorts who received the 3HP regimen. In the single-nucleotide polymorphism (S...

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Bibliographic Details
Main Authors: Meng-Rui Lee, Hung-Ling Huang, Shu-Wen Lin, Meng-Hsuan Cheng, Ya-Ting Lin, So-Yi Chang, Bo-Shiun Yan, Ching-Hua Kuo, Po-Liang Lu, Jann-Yuan Wang, Inn-Wen Chong
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Journal of Clinical Medicine
Subjects:
isoniazid
<i>N-acetyltransferase 2</i>
rifapentine
latent tuberculosis infection
systemic drug reaction
Online Access:https://www.mdpi.com/2077-0383/8/6/812

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https://www.mdpi.com/2077-0383/8/6/812

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