Myocardial Disease and Long-Distance Space Travel: Solving the Radiation Problem
Radiation-induced cardiovascular disease is a well-known complication of radiation exposure. Over the last few years, planning for deep space missions has increased interest in the effects of space radiation on the cardiovascular system, as an increasing number of astronauts will be exposed to space...
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doaj-bd92e417992740e295942ac2d7d073f02021-02-12T04:15:59ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2021-02-01810.3389/fcvm.2021.631985631985Myocardial Disease and Long-Distance Space Travel: Solving the Radiation ProblemManon Meerman0Manon Meerman1Tom C. L. Bracco Gartner2Tom C. L. Bracco Gartner3Jan Willem Buikema4Jan Willem Buikema5Sean M. Wu6Sailay Siddiqi7Carlijn V. C. Bouten8K. Jane Grande-Allen9Willem J. L. Suyker10Jesper Hjortnaes11Jesper Hjortnaes12Division Heart and Lung, Department of Cardiothoracic Surgery, University Medical Center Utrecht, Utrecht, NetherlandsRegenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht, NetherlandsDivision Heart and Lung, Department of Cardiothoracic Surgery, University Medical Center Utrecht, Utrecht, NetherlandsRegenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht, NetherlandsRegenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht, NetherlandsDepartment of Cardiology, University Medical Center Utrecht, Utrecht, NetherlandsDivision of Cardiovascular Medicine, Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, United StatesDepartment of Cardiothoracic Surgery, Radboud University, Nijmegen, NetherlandsDepartment of Biomedical Engineering, Technical University Eindhoven, Eindhoven, NetherlandsDepartment of Bioengineering, Rice University, Houston, TX, United StatesDivision Heart and Lung, Department of Cardiothoracic Surgery, University Medical Center Utrecht, Utrecht, NetherlandsRegenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht, NetherlandsDivision Heart and Lung, Department of Cardiothoracic Surgery, Leiden University Medical Center, Leiden, NetherlandsRadiation-induced cardiovascular disease is a well-known complication of radiation exposure. Over the last few years, planning for deep space missions has increased interest in the effects of space radiation on the cardiovascular system, as an increasing number of astronauts will be exposed to space radiation for longer periods of time. Research has shown that exposure to different types of particles found in space radiation can lead to the development of diverse cardiovascular disease via fibrotic myocardial remodeling, accelerated atherosclerosis and microvascular damage. Several underlying mechanisms for radiation-induced cardiovascular disease have been identified, but many aspects of the pathophysiology remain unclear. Existing pharmacological compounds have been evaluated to protect the cardiovascular system from space radiation-induced damage, but currently no radioprotective compounds have been approved. This review critically analyzes the effects of space radiation on the cardiovascular system, the underlying mechanisms and potential countermeasures to space radiation-induced cardiovascular disease.https://www.frontiersin.org/articles/10.3389/fcvm.2021.631985/fullradiation-induced cardiovascular diseasecardiovascular systemspace radiationlong-distance space travelexperimental studiescountermeasures |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Manon Meerman Manon Meerman Tom C. L. Bracco Gartner Tom C. L. Bracco Gartner Jan Willem Buikema Jan Willem Buikema Sean M. Wu Sailay Siddiqi Carlijn V. C. Bouten K. Jane Grande-Allen Willem J. L. Suyker Jesper Hjortnaes Jesper Hjortnaes |
spellingShingle |
Manon Meerman Manon Meerman Tom C. L. Bracco Gartner Tom C. L. Bracco Gartner Jan Willem Buikema Jan Willem Buikema Sean M. Wu Sailay Siddiqi Carlijn V. C. Bouten K. Jane Grande-Allen Willem J. L. Suyker Jesper Hjortnaes Jesper Hjortnaes Myocardial Disease and Long-Distance Space Travel: Solving the Radiation Problem Frontiers in Cardiovascular Medicine radiation-induced cardiovascular disease cardiovascular system space radiation long-distance space travel experimental studies countermeasures |
author_facet |
Manon Meerman Manon Meerman Tom C. L. Bracco Gartner Tom C. L. Bracco Gartner Jan Willem Buikema Jan Willem Buikema Sean M. Wu Sailay Siddiqi Carlijn V. C. Bouten K. Jane Grande-Allen Willem J. L. Suyker Jesper Hjortnaes Jesper Hjortnaes |
author_sort |
Manon Meerman |
title |
Myocardial Disease and Long-Distance Space Travel: Solving the Radiation Problem |
title_short |
Myocardial Disease and Long-Distance Space Travel: Solving the Radiation Problem |
title_full |
Myocardial Disease and Long-Distance Space Travel: Solving the Radiation Problem |
title_fullStr |
Myocardial Disease and Long-Distance Space Travel: Solving the Radiation Problem |
title_full_unstemmed |
Myocardial Disease and Long-Distance Space Travel: Solving the Radiation Problem |
title_sort |
myocardial disease and long-distance space travel: solving the radiation problem |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cardiovascular Medicine |
issn |
2297-055X |
publishDate |
2021-02-01 |
description |
Radiation-induced cardiovascular disease is a well-known complication of radiation exposure. Over the last few years, planning for deep space missions has increased interest in the effects of space radiation on the cardiovascular system, as an increasing number of astronauts will be exposed to space radiation for longer periods of time. Research has shown that exposure to different types of particles found in space radiation can lead to the development of diverse cardiovascular disease via fibrotic myocardial remodeling, accelerated atherosclerosis and microvascular damage. Several underlying mechanisms for radiation-induced cardiovascular disease have been identified, but many aspects of the pathophysiology remain unclear. Existing pharmacological compounds have been evaluated to protect the cardiovascular system from space radiation-induced damage, but currently no radioprotective compounds have been approved. This review critically analyzes the effects of space radiation on the cardiovascular system, the underlying mechanisms and potential countermeasures to space radiation-induced cardiovascular disease. |
topic |
radiation-induced cardiovascular disease cardiovascular system space radiation long-distance space travel experimental studies countermeasures |
url |
https://www.frontiersin.org/articles/10.3389/fcvm.2021.631985/full |
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