The furosemide stress test: current use and future potential
Loop diuretics are among the most widely used drugs worldwide and are commonly employed in the management of complications associated with acute kidney injury (AKI), namely volume overload and electrolyte management. The use of loop diuretics in critically ill patients with AKI is paramount to preve...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
Taylor & Francis Group
2021-01-01
|
Series: | Renal Failure |
Subjects: | |
Online Access: | http://dx.doi.org/10.1080/0886022X.2021.1906701 |
id |
doaj-bd9d2014e2c64f2995ec889b283022bc |
---|---|
record_format |
Article |
spelling |
doaj-bd9d2014e2c64f2995ec889b283022bc2021-05-13T09:30:27ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492021-01-0143183083910.1080/0886022X.2021.19067011906701The furosemide stress test: current use and future potentialBlaithin A. McMahon0Lakhmir S. Chawla1Medical University of South Carolina, Department of Medicine, Medical University of South CarolinaDepartment of Medicine, Veterans Affairs Medical CenterLoop diuretics are among the most widely used drugs worldwide and are commonly employed in the management of complications associated with acute kidney injury (AKI), namely volume overload and electrolyte management. The use of loop diuretics in critically ill patients with AKI is paramount to preventing or treating pulmonary edema. The naturetic response to a loop diuretic is based on its unique renal pharmacology. Our review article summarizes the pharmacology of furosemide in the intact nephron and discusses how this response might be altered by the presence of AKI. We discuss the increasing body of literature on the latest clinical utility of furosemide namely, it’s challenge test, known as the furosemide stress test which has highlighted a new and novel role for furosemide over the past number of years. This test assists with the identification of AKI subjects at higher risk of AKI progression and the need for renal replacement therapy. The stress test can also predict cessation of continuous renal replacement therapy in patients with established AKI. On the basis of the evidence presented in this review, we propose future potential studies of furosemide in AKI.http://dx.doi.org/10.1080/0886022X.2021.1906701furosemideacute kidney injurystress testrenal replacement therapyrisk assessment |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Blaithin A. McMahon Lakhmir S. Chawla |
spellingShingle |
Blaithin A. McMahon Lakhmir S. Chawla The furosemide stress test: current use and future potential Renal Failure furosemide acute kidney injury stress test renal replacement therapy risk assessment |
author_facet |
Blaithin A. McMahon Lakhmir S. Chawla |
author_sort |
Blaithin A. McMahon |
title |
The furosemide stress test: current use and future potential |
title_short |
The furosemide stress test: current use and future potential |
title_full |
The furosemide stress test: current use and future potential |
title_fullStr |
The furosemide stress test: current use and future potential |
title_full_unstemmed |
The furosemide stress test: current use and future potential |
title_sort |
furosemide stress test: current use and future potential |
publisher |
Taylor & Francis Group |
series |
Renal Failure |
issn |
0886-022X 1525-6049 |
publishDate |
2021-01-01 |
description |
Loop diuretics are among the most widely used drugs worldwide and are commonly employed in the management of complications associated with acute kidney injury (AKI), namely volume overload and electrolyte management. The use of loop diuretics in critically ill patients with AKI is paramount to preventing or treating pulmonary edema. The naturetic response to a loop diuretic is based on its unique renal pharmacology. Our review article summarizes the pharmacology of furosemide in the intact nephron and discusses how this response might be altered by the presence of AKI. We discuss the increasing body of literature on the latest clinical utility of furosemide namely, it’s challenge test, known as the furosemide stress test which has highlighted a new and novel role for furosemide over the past number of years. This test assists with the identification of AKI subjects at higher risk of AKI progression and the need for renal replacement therapy. The stress test can also predict cessation of continuous renal replacement therapy in patients with established AKI. On the basis of the evidence presented in this review, we propose future potential studies of furosemide in AKI. |
topic |
furosemide acute kidney injury stress test renal replacement therapy risk assessment |
url |
http://dx.doi.org/10.1080/0886022X.2021.1906701 |
work_keys_str_mv |
AT blaithinamcmahon thefurosemidestresstestcurrentuseandfuturepotential AT lakhmirschawla thefurosemidestresstestcurrentuseandfuturepotential AT blaithinamcmahon furosemidestresstestcurrentuseandfuturepotential AT lakhmirschawla furosemidestresstestcurrentuseandfuturepotential |
_version_ |
1721442355322552320 |