PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis

Although protein tyrosine kinases are being explored as antifibrotic agents for the treatment of systemic sclerosis, little is known about the function of counteractive protein tyrosine phosphatases in this context. Here, the authors show that PTP4A1 is highly expressed by fibroblasts from patients...

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Main Authors:	Cristiano Sacchetti, Yunpeng Bai, Stephanie M. Stanford, Paola Di Benedetto, Paola Cipriani, Eugenio Santelli, Sonsoles Piera-Velazquez, Vladimir Chernitskiy, William B. Kiosses, Arnold Ceponis, Klaus H. Kaestner, Francesco Boin, Sergio A. Jimenez, Roberto Giacomelli, Zhong-Yin Zhang, Nunzio Bottini
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-01168-1

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spelling	doaj-bda2249f57354c398a9b7c97bc41a7fd2021-05-11T07:21:37ZengNature Publishing GroupNature Communications2041-17232017-10-018111410.1038/s41467-017-01168-1PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosisCristiano Sacchetti0Yunpeng Bai1Stephanie M. Stanford2Paola Di Benedetto3Paola Cipriani4Eugenio Santelli5Sonsoles Piera-Velazquez6Vladimir Chernitskiy7William B. Kiosses8Arnold Ceponis9Klaus H. Kaestner10Francesco Boin11Sergio A. Jimenez12Roberto Giacomelli13Zhong-Yin Zhang14Nunzio Bottini15Division of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San DiegoDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue UniversityDivision of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San DiegoRheumatology Division, Department of Biotechnological and Applied Clinical Sciences, University of L’AquilaRheumatology Division, Department of Biotechnological and Applied Clinical Sciences, University of L’AquilaDivision of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San DiegoScleroderma Center and Jefferson Institute of Molecular MedicineDivision of Rheumatology, Department of Medicine, University of California San FranciscoCore Microscopy Facility, The Scripps Research InstituteDivision of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San DiegoDepartment of Genetics, Perelman School of Medicine, University of PennsylvaniaDivision of Rheumatology, Department of Medicine, University of California San FranciscoScleroderma Center and Jefferson Institute of Molecular MedicineRheumatology Division, Department of Biotechnological and Applied Clinical Sciences, University of L’AquilaDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue UniversityDivision of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San DiegoAlthough protein tyrosine kinases are being explored as antifibrotic agents for the treatment of systemic sclerosis, little is known about the function of counteractive protein tyrosine phosphatases in this context. Here, the authors show that PTP4A1 is highly expressed by fibroblasts from patients with systemic sclerosis and promotes TGFβ activity via SRC–ERK–SMAD3 signaling.https://doi.org/10.1038/s41467-017-01168-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Cristiano Sacchetti Yunpeng Bai Stephanie M. Stanford Paola Di Benedetto Paola Cipriani Eugenio Santelli Sonsoles Piera-Velazquez Vladimir Chernitskiy William B. Kiosses Arnold Ceponis Klaus H. Kaestner Francesco Boin Sergio A. Jimenez Roberto Giacomelli Zhong-Yin Zhang Nunzio Bottini
spellingShingle	Cristiano Sacchetti Yunpeng Bai Stephanie M. Stanford Paola Di Benedetto Paola Cipriani Eugenio Santelli Sonsoles Piera-Velazquez Vladimir Chernitskiy William B. Kiosses Arnold Ceponis Klaus H. Kaestner Francesco Boin Sergio A. Jimenez Roberto Giacomelli Zhong-Yin Zhang Nunzio Bottini PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis Nature Communications
author_facet	Cristiano Sacchetti Yunpeng Bai Stephanie M. Stanford Paola Di Benedetto Paola Cipriani Eugenio Santelli Sonsoles Piera-Velazquez Vladimir Chernitskiy William B. Kiosses Arnold Ceponis Klaus H. Kaestner Francesco Boin Sergio A. Jimenez Roberto Giacomelli Zhong-Yin Zhang Nunzio Bottini
author_sort	Cristiano Sacchetti
title	PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis
title_short	PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis
title_full	PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis
title_fullStr	PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis
title_full_unstemmed	PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis
title_sort	ptp4a1 promotes tgfβ signaling and fibrosis in systemic sclerosis
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-10-01
description	Although protein tyrosine kinases are being explored as antifibrotic agents for the treatment of systemic sclerosis, little is known about the function of counteractive protein tyrosine phosphatases in this context. Here, the authors show that PTP4A1 is highly expressed by fibroblasts from patients with systemic sclerosis and promotes TGFβ activity via SRC–ERK–SMAD3 signaling.
url	https://doi.org/10.1038/s41467-017-01168-1
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PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis

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