Genetically altered fields in head and neck cancer and second field tumor
The concept of field cancerization has been ever changing since its first description by Slaughter et al in 1953.Field cancerization explains the mechanisms by which second primary tumors (SPTs) develop. SPTs are the tumors, which develop in the oral cavity in succession to the primary malignant tum...
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2014-01-01
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doaj-bda299efd4a64df5977c33e2d23344402020-12-02T16:15:25ZengThieme Medical and Scientific Publishers Pvt. Ltd.South Asian Journal of Cancer2278-330X2278-43062014-01-013315115310.4103/2278-330X.136766Genetically altered fields in head and neck cancer and second field tumorRobin SabharwalAshish MahendraNinad J MoonParul GuptaAshish JainShivangi GuptaThe concept of field cancerization has been ever changing since its first description by Slaughter et al in 1953.Field cancerization explains the mechanisms by which second primary tumors (SPTs) develop. SPTs are the tumors, which develop in the oral cavity in succession to the primary malignant tumors, which might vary in duration ranging from few months to years. Conceivably, a population of daughter cells with early genetic changes (without histopathology) remains in the organ, demonstrating the concept of field cancerization. This review explains the concept of field cancerization and various field theories along with molecular basis of field formation.http://journal.sajc.org/article.asp?issn=2278-330X;year=2014;volume=3;issue=3;spage=151;epage=153;aulast=SabharwalSecond primary tumorhead and neck squamous cell carcinomatumor adjacent mucosaupper aerodigestive tract |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Robin Sabharwal Ashish Mahendra Ninad J Moon Parul Gupta Ashish Jain Shivangi Gupta |
spellingShingle |
Robin Sabharwal Ashish Mahendra Ninad J Moon Parul Gupta Ashish Jain Shivangi Gupta Genetically altered fields in head and neck cancer and second field tumor South Asian Journal of Cancer Second primary tumor head and neck squamous cell carcinoma tumor adjacent mucosa upper aerodigestive tract |
author_facet |
Robin Sabharwal Ashish Mahendra Ninad J Moon Parul Gupta Ashish Jain Shivangi Gupta |
author_sort |
Robin Sabharwal |
title |
Genetically altered fields in head and neck cancer and second field tumor |
title_short |
Genetically altered fields in head and neck cancer and second field tumor |
title_full |
Genetically altered fields in head and neck cancer and second field tumor |
title_fullStr |
Genetically altered fields in head and neck cancer and second field tumor |
title_full_unstemmed |
Genetically altered fields in head and neck cancer and second field tumor |
title_sort |
genetically altered fields in head and neck cancer and second field tumor |
publisher |
Thieme Medical and Scientific Publishers Pvt. Ltd. |
series |
South Asian Journal of Cancer |
issn |
2278-330X 2278-4306 |
publishDate |
2014-01-01 |
description |
The concept of field cancerization has been ever changing since its first description by Slaughter et al in 1953.Field cancerization explains the mechanisms by which second primary tumors (SPTs) develop. SPTs are the tumors, which develop in the oral cavity in succession to the primary malignant tumors, which might vary in duration ranging from few months to years. Conceivably, a population of daughter cells with early genetic changes (without histopathology) remains in the organ, demonstrating the concept of field cancerization. This review explains the concept of field cancerization and various field theories along with molecular basis of field formation. |
topic |
Second primary tumor head and neck squamous cell carcinoma tumor adjacent mucosa upper aerodigestive tract |
url |
http://journal.sajc.org/article.asp?issn=2278-330X;year=2014;volume=3;issue=3;spage=151;epage=153;aulast=Sabharwal |
work_keys_str_mv |
AT robinsabharwal geneticallyalteredfieldsinheadandneckcancerandsecondfieldtumor AT ashishmahendra geneticallyalteredfieldsinheadandneckcancerandsecondfieldtumor AT ninadjmoon geneticallyalteredfieldsinheadandneckcancerandsecondfieldtumor AT parulgupta geneticallyalteredfieldsinheadandneckcancerandsecondfieldtumor AT ashishjain geneticallyalteredfieldsinheadandneckcancerandsecondfieldtumor AT shivangigupta geneticallyalteredfieldsinheadandneckcancerandsecondfieldtumor |
_version_ |
1724405154265956352 |