Pinnisterols A–C, New 9,11-Secosterols from a Gorgonian Pinnigorgia sp.
Three new 9,11-secosterols, pinnisterols A–C (1–3), were isolated from a gorgonian coral Pinnigorgia sp., collected off the waters of Taiwan. The structures of these compounds were elucidated on the basis of spectroscopic methods. The new sterols 1 and 3 displayed significant inhibitory effects on t...
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MDPI AG
2016-01-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/14/1/12 |
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doaj-bda3869c346141d699a1fb502dc946a82020-11-24T23:05:18ZengMDPI AGMarine Drugs1660-33972016-01-011411210.3390/md14010012md14010012Pinnisterols A–C, New 9,11-Secosterols from a Gorgonian Pinnigorgia sp.Yu-Chia Chang0Liang-Mou Kuo1Tsong-Long Hwang2Jessica Yeh3Zhi-Hong Wen4Lee-Shing Fang5Yang-Chang Wu6Chan-Shing Lin7Jyh-Horng Sheu8Ping-Jyun Sung9Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, TaiwanGraduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanGraduate Institute of Natural Products, School of Traditional Chinese Medicine, College of Medicine and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, TaiwanDepartment of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, TaiwanDoctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, TaiwanDepartment of Sport, Health, and Leisure, Cheng Shiu University, Kaohsiung 833, TaiwanSchool of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, TaiwanDoctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, TaiwanDoctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, TaiwanNational Museum of Marine Biology & Aquarium, Pingtung 944, TaiwanThree new 9,11-secosterols, pinnisterols A–C (1–3), were isolated from a gorgonian coral Pinnigorgia sp., collected off the waters of Taiwan. The structures of these compounds were elucidated on the basis of spectroscopic methods. The new sterols 1 and 3 displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils, and sterol 1 was found to show moderate cytotoxicity in hepatic stellate cells (HSCs).http://www.mdpi.com/1660-3397/14/1/12secosterolgorgonianPinnigorgiaanti-inflammatorysuperoxide anionelastasecytotoxicityHSCs |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Yu-Chia Chang Liang-Mou Kuo Tsong-Long Hwang Jessica Yeh Zhi-Hong Wen Lee-Shing Fang Yang-Chang Wu Chan-Shing Lin Jyh-Horng Sheu Ping-Jyun Sung |
| spellingShingle |
Yu-Chia Chang Liang-Mou Kuo Tsong-Long Hwang Jessica Yeh Zhi-Hong Wen Lee-Shing Fang Yang-Chang Wu Chan-Shing Lin Jyh-Horng Sheu Ping-Jyun Sung Pinnisterols A–C, New 9,11-Secosterols from a Gorgonian Pinnigorgia sp. Marine Drugs secosterol gorgonian Pinnigorgia anti-inflammatory superoxide anion elastase cytotoxicity HSCs |
| author_facet |
Yu-Chia Chang Liang-Mou Kuo Tsong-Long Hwang Jessica Yeh Zhi-Hong Wen Lee-Shing Fang Yang-Chang Wu Chan-Shing Lin Jyh-Horng Sheu Ping-Jyun Sung |
| author_sort |
Yu-Chia Chang |
| title |
Pinnisterols A–C, New 9,11-Secosterols from a Gorgonian Pinnigorgia sp. |
| title_short |
Pinnisterols A–C, New 9,11-Secosterols from a Gorgonian Pinnigorgia sp. |
| title_full |
Pinnisterols A–C, New 9,11-Secosterols from a Gorgonian Pinnigorgia sp. |
| title_fullStr |
Pinnisterols A–C, New 9,11-Secosterols from a Gorgonian Pinnigorgia sp. |
| title_full_unstemmed |
Pinnisterols A–C, New 9,11-Secosterols from a Gorgonian Pinnigorgia sp. |
| title_sort |
pinnisterols a–c, new 9,11-secosterols from a gorgonian pinnigorgia sp. |
| publisher |
MDPI AG |
| series |
Marine Drugs |
| issn |
1660-3397 |
| publishDate |
2016-01-01 |
| description |
Three new 9,11-secosterols, pinnisterols A–C (1–3), were isolated from a gorgonian coral Pinnigorgia sp., collected off the waters of Taiwan. The structures of these compounds were elucidated on the basis of spectroscopic methods. The new sterols 1 and 3 displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils, and sterol 1 was found to show moderate cytotoxicity in hepatic stellate cells (HSCs). |
| topic |
secosterol gorgonian Pinnigorgia anti-inflammatory superoxide anion elastase cytotoxicity HSCs |
| url |
http://www.mdpi.com/1660-3397/14/1/12 |
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