Evaluation the Hypo and Antihyperglycemic Activity of Cactus Seeds Extracts (Opuntia ficus-indica.L)

• Main Authors: FARAH KENZA BENATTIA, ZOHEIR ARRAR, YOUSSEF KHABBAL
• Format: Article
• Language: English
• Published: Phytochemistry & Organic Synthesis Laboratory 2017-11-01
• Series: PhytoChem & BioSub Journal
• Online Access: https://drive.google.com/file/d/1F3XBsH4izJl4rjT5o9D0rQjSMVXx_gu0/view?usp=sharing

Context : Diabetes mellitus is a serious metabolic disease which has several complications, in addition to synthetic drugs, the search for indigenous and diabetic agents still continues and provided many clinically useful drugs based on natural products and theirs analogus from various medicinal plants. Aims: To determine the hypoglycemic effect of prickly pear seed extracts (Opuntia ficus-indica) to achieve a primary pharmacological screening contained in these extracts (aqueous, hydro-ethanol). Methods: The experiment was performed on white rats from a Swiss race Sprague-Dawley subject to oral glucose tolerance test, and the glycemia was successively determined every half hour for a period of 3 hours in the capillary blood the tail vein using a glucometer. Results: The results showed that the administration of two extracts of prickly pear seeds dose (400mg / kg) reduced blood glucose levels with a maximum decrease at an hour and a halfcompared to the control group. Conclusion: This study can be a base for a promising work to highlight the bioactive molecules responsible for this anti-hyperglycemic activity present in extracts made from prickly pear seeds.