Targeted Therapies for Pediatric AML: Gaps and Perspective

Targeted Therapies for Pediatric AML: Gaps and Perspective

Acute myeloid leukemia (AML) is a hematopoietic disorder characterized by numerous cytogenetic and molecular aberrations that accounts for ~25% of childhood leukemia diagnoses. The outcome of children with AML has increased remarkably over the past 30 years, with current survival rates up to 70%, ma...

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Bibliographic Details
Main Authors: Annalisa Lonetti, Andrea Pession, Riccardo Masetti
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Pediatrics
Subjects:
Pediatric AML
targeted therapy
FLT-3 inhibitors
Hedgehog pathway inhibitors
DOT1L inhibitors
Online Access:https://www.frontiersin.org/article/10.3389/fped.2019.00463/full

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