A broadly neutralizing anti-influenza antibody reveals ongoing capacity of haemagglutinin-specific memory B cells to evolve

A broadly neutralizing anti-influenza antibody reveals ongoing capacity of haemagglutinin-specific memory B cells to evolve

A major goal of vaccine design is to protect against a broad range of pathogen strains. Here the authors isolate a new broadly neutralizing antibody against influenza haemagglutinin from human memory B cells, and identify mutations that increase and broaden the neutralization towards H5 HA subtype.

Bibliographic Details
Main Authors: Ying Fu, Zhen Zhang, Jared Sheehan, Yuval Avnir, Callie Ridenour, Thomas Sachnik, Jiusong Sun, M. Jaber Hossain, Li-Mei Chen, Quan Zhu, Ruben O. Donis, Wayne A. Marasco
Format: Article
Language:English
Published: Nature Publishing Group 2016-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12780
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spelling doaj-bdbf5311bd834c67bd4c3bb2bd03af222021-05-11T11:10:05ZengNature Publishing GroupNature Communications2041-17232016-09-017111310.1038/ncomms12780A broadly neutralizing anti-influenza antibody reveals ongoing capacity of haemagglutinin-specific memory B cells to evolveYing Fu0Zhen Zhang1Jared Sheehan2Yuval Avnir3Callie Ridenour4Thomas Sachnik5Jiusong Sun6M. Jaber Hossain7Li-Mei Chen8Quan Zhu9Ruben O. Donis10Wayne A. Marasco11Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical SchoolDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical SchoolDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical SchoolDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical SchoolInfluenza Division, Centers for Disease Control and Prevention, National Center for Immunization and Respiratory DiseasesDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical SchoolDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical SchoolInfluenza Division, Centers for Disease Control and Prevention, National Center for Immunization and Respiratory DiseasesInfluenza Division, Centers for Disease Control and Prevention, National Center for Immunization and Respiratory DiseasesDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical SchoolInfluenza Division, Centers for Disease Control and Prevention, National Center for Immunization and Respiratory DiseasesDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical SchoolA major goal of vaccine design is to protect against a broad range of pathogen strains. Here the authors isolate a new broadly neutralizing antibody against influenza haemagglutinin from human memory B cells, and identify mutations that increase and broaden the neutralization towards H5 HA subtype.https://doi.org/10.1038/ncomms12780
collection DOAJ
language English
format Article
sources DOAJ
author Ying Fu
Zhen Zhang
Jared Sheehan
Yuval Avnir
Callie Ridenour
Thomas Sachnik
Jiusong Sun
M. Jaber Hossain
Li-Mei Chen
Quan Zhu
Ruben O. Donis
Wayne A. Marasco
spellingShingle Ying Fu
Zhen Zhang
Jared Sheehan
Yuval Avnir
Callie Ridenour
Thomas Sachnik
Jiusong Sun
M. Jaber Hossain
Li-Mei Chen
Quan Zhu
Ruben O. Donis
Wayne A. Marasco
A broadly neutralizing anti-influenza antibody reveals ongoing capacity of haemagglutinin-specific memory B cells to evolve
Nature Communications
author_facet Ying Fu
Zhen Zhang
Jared Sheehan
Yuval Avnir
Callie Ridenour
Thomas Sachnik
Jiusong Sun
M. Jaber Hossain
Li-Mei Chen
Quan Zhu
Ruben O. Donis
Wayne A. Marasco
author_sort Ying Fu
title A broadly neutralizing anti-influenza antibody reveals ongoing capacity of haemagglutinin-specific memory B cells to evolve
title_short A broadly neutralizing anti-influenza antibody reveals ongoing capacity of haemagglutinin-specific memory B cells to evolve
title_full A broadly neutralizing anti-influenza antibody reveals ongoing capacity of haemagglutinin-specific memory B cells to evolve
title_fullStr A broadly neutralizing anti-influenza antibody reveals ongoing capacity of haemagglutinin-specific memory B cells to evolve
title_full_unstemmed A broadly neutralizing anti-influenza antibody reveals ongoing capacity of haemagglutinin-specific memory B cells to evolve
title_sort broadly neutralizing anti-influenza antibody reveals ongoing capacity of haemagglutinin-specific memory b cells to evolve
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-09-01
description A major goal of vaccine design is to protect against a broad range of pathogen strains. Here the authors isolate a new broadly neutralizing antibody against influenza haemagglutinin from human memory B cells, and identify mutations that increase and broaden the neutralization towards H5 HA subtype.
url https://doi.org/10.1038/ncomms12780
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