Mitochondrial Aging and Age-Related Dysfunction of Mitochondria
Age-related changes in mitochondria are associated with decline in mitochondrial function. With advanced age, mitochondrial DNA volume, integrity and functionality decrease due to accumulation of mutations and oxidative damage induced by reactive oxygen species (ROS). In aged subjects, mitochondria...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2014-01-01
|
Series: | BioMed Research International |
Online Access: | http://dx.doi.org/10.1155/2014/238463 |
id |
doaj-bdcc7e0492624b9f854c55e7109f59dc |
---|---|
record_format |
Article |
spelling |
doaj-bdcc7e0492624b9f854c55e7109f59dc2020-11-24T23:46:03ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/238463238463Mitochondrial Aging and Age-Related Dysfunction of MitochondriaDimitry A. Chistiakov0Igor A. Sobenin1Victor V. Revin2Alexander N. Orekhov3Yuri V. Bobryshev4Department of Medical Nanobiotechnology, Pirogov Russian State Medical University, Moscow 117997, RussiaLaboratory of Medical Genetics, Russian Cardiology Research and Production Complex, Moscow 121552, RussiaBiological Faculty, N.P. Ogaryov Mordovian State University, Saransk 430005, RussiaLaboratory of Cellular Mechanisms of Atherogenesis, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow 125315, RussiaBiological Faculty, N.P. Ogaryov Mordovian State University, Saransk 430005, RussiaAge-related changes in mitochondria are associated with decline in mitochondrial function. With advanced age, mitochondrial DNA volume, integrity and functionality decrease due to accumulation of mutations and oxidative damage induced by reactive oxygen species (ROS). In aged subjects, mitochondria are characterized by impaired function such as lowered oxidative capacity, reduced oxidative phosphorylation, decreased ATP production, significant increase in ROS generation, and diminished antioxidant defense. Mitochondrial biogenesis declines with age due to alterations in mitochondrial dynamics and inhibition of mitophagy, an autophagy process that removes dysfunctional mitochondria. Age-dependent abnormalities in mitochondrial quality control further weaken and impair mitochondrial function. In aged tissues, enhanced mitochondria-mediated apoptosis contributes to an increase in the percentage of apoptotic cells. However, implementation of strategies such as caloric restriction and regular physical training may delay mitochondrial aging and attenuate the age-related phenotype in humans.http://dx.doi.org/10.1155/2014/238463 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dimitry A. Chistiakov Igor A. Sobenin Victor V. Revin Alexander N. Orekhov Yuri V. Bobryshev |
spellingShingle |
Dimitry A. Chistiakov Igor A. Sobenin Victor V. Revin Alexander N. Orekhov Yuri V. Bobryshev Mitochondrial Aging and Age-Related Dysfunction of Mitochondria BioMed Research International |
author_facet |
Dimitry A. Chistiakov Igor A. Sobenin Victor V. Revin Alexander N. Orekhov Yuri V. Bobryshev |
author_sort |
Dimitry A. Chistiakov |
title |
Mitochondrial Aging and Age-Related Dysfunction of Mitochondria |
title_short |
Mitochondrial Aging and Age-Related Dysfunction of Mitochondria |
title_full |
Mitochondrial Aging and Age-Related Dysfunction of Mitochondria |
title_fullStr |
Mitochondrial Aging and Age-Related Dysfunction of Mitochondria |
title_full_unstemmed |
Mitochondrial Aging and Age-Related Dysfunction of Mitochondria |
title_sort |
mitochondrial aging and age-related dysfunction of mitochondria |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2014-01-01 |
description |
Age-related changes in mitochondria are associated with decline in mitochondrial function. With advanced age, mitochondrial DNA volume, integrity and functionality decrease due to accumulation of mutations and oxidative damage induced by reactive oxygen species (ROS). In aged subjects, mitochondria are characterized by impaired function such as lowered oxidative capacity, reduced oxidative phosphorylation, decreased ATP production, significant increase in ROS generation, and diminished antioxidant defense. Mitochondrial biogenesis declines with age due to alterations in mitochondrial dynamics and inhibition of mitophagy, an autophagy process that removes dysfunctional mitochondria. Age-dependent abnormalities in mitochondrial quality control further weaken and impair mitochondrial function. In aged tissues, enhanced mitochondria-mediated apoptosis contributes to an increase in the percentage of apoptotic cells. However, implementation of strategies such as caloric restriction and regular physical training may delay mitochondrial aging and attenuate the age-related phenotype in humans. |
url |
http://dx.doi.org/10.1155/2014/238463 |
work_keys_str_mv |
AT dimitryachistiakov mitochondrialagingandagerelateddysfunctionofmitochondria AT igorasobenin mitochondrialagingandagerelateddysfunctionofmitochondria AT victorvrevin mitochondrialagingandagerelateddysfunctionofmitochondria AT alexandernorekhov mitochondrialagingandagerelateddysfunctionofmitochondria AT yurivbobryshev mitochondrialagingandagerelateddysfunctionofmitochondria |
_version_ |
1725494852243685376 |