NMDA Receptors of Gastric-Projecting Neurons in the Dorsal Motor Nucleus of the Vagus Mediate the Regulation of Gastric Emptying by EA at Weishu (BL21)

NMDA Receptors of Gastric-Projecting Neurons in the Dorsal Motor Nucleus of the Vagus Mediate the Regulation of Gastric Emptying by EA at Weishu (BL21)

A large number of studies have been conducted to explore the efficacy of electroacupuncture (EA) for the treatment of gastrointestinal motility. While several lines of evidence addressed the basic mechanism of EA on gastrointestinal motility regarding effects of limb and abdomen points, the mechanis...

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Main Authors: Xin Zhang, Bin Cheng, Xianghong Jing, Yongfa Qiao, Xinyan Gao, Huijuan Yu, Bing Zhu, Haifa Qiao
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Evidence-Based Complementary and Alternative Medicine
Online Access:http://dx.doi.org/10.1155/2012/583479
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spelling doaj-bdcded40abc64904ac01922699d2d8a22020-11-25T00:10:45ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882012-01-01201210.1155/2012/583479583479NMDA Receptors of Gastric-Projecting Neurons in the Dorsal Motor Nucleus of the Vagus Mediate the Regulation of Gastric Emptying by EA at Weishu (BL21)Xin Zhang0Bin Cheng1Xianghong Jing2Yongfa Qiao3Xinyan Gao4Huijuan Yu5Bing Zhu6Haifa Qiao7Neuroscience Program, Shandong University of Traditional Chinese Medicine, Changqing University Park, Jinan 250355, ChinaNeuroscience Program, Shandong University of Traditional Chinese Medicine, Changqing University Park, Jinan 250355, ChinaInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, 16 Nanxiaojie, Dongzhimeinei, Beijing 100700, ChinaQingdao Haici Medical Group, 4 Renmin Road, Qingdao 266033, ChinaInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, 16 Nanxiaojie, Dongzhimeinei, Beijing 100700, ChinaNeuroscience Program, Shandong University of Traditional Chinese Medicine, Changqing University Park, Jinan 250355, ChinaInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, 16 Nanxiaojie, Dongzhimeinei, Beijing 100700, ChinaNeuroscience Program, Shandong University of Traditional Chinese Medicine, Changqing University Park, Jinan 250355, ChinaA large number of studies have been conducted to explore the efficacy of electroacupuncture (EA) for the treatment of gastrointestinal motility. While several lines of evidence addressed the basic mechanism of EA on gastrointestinal motility regarding effects of limb and abdomen points, the mechanism for effects of the back points on gastric motility still remains unclear. Here we report that the NMDA receptor (NMDAR) antagonist kynurenic acid inhibited the gastric emptying increase induced by high-intensity EA at BL21 and agonist NMDA enhanced the effect of the same treatment. EA at BL21 enhanced NMDAR, but not AMPA receptor (AMPAR) component of miniature excitatory postsynaptic current (mEPSC) in gastric-projecting neurons of the dorsal motor nucleus of the vagus (DMV). In sum, our data demonstrate an important role of NMDAR-mediated synaptic transmission of gastric-projecting DMV neurons in mediating EA at BL21-induced enhancement of gastric emptying.http://dx.doi.org/10.1155/2012/583479
collection DOAJ
language English
format Article
sources DOAJ
author Xin Zhang
Bin Cheng
Xianghong Jing
Yongfa Qiao
Xinyan Gao
Huijuan Yu
Bing Zhu
Haifa Qiao
spellingShingle Xin Zhang
Bin Cheng
Xianghong Jing
Yongfa Qiao
Xinyan Gao
Huijuan Yu
Bing Zhu
Haifa Qiao
NMDA Receptors of Gastric-Projecting Neurons in the Dorsal Motor Nucleus of the Vagus Mediate the Regulation of Gastric Emptying by EA at Weishu (BL21)
Evidence-Based Complementary and Alternative Medicine
author_facet Xin Zhang
Bin Cheng
Xianghong Jing
Yongfa Qiao
Xinyan Gao
Huijuan Yu
Bing Zhu
Haifa Qiao
author_sort Xin Zhang
title NMDA Receptors of Gastric-Projecting Neurons in the Dorsal Motor Nucleus of the Vagus Mediate the Regulation of Gastric Emptying by EA at Weishu (BL21)
title_short NMDA Receptors of Gastric-Projecting Neurons in the Dorsal Motor Nucleus of the Vagus Mediate the Regulation of Gastric Emptying by EA at Weishu (BL21)
title_full NMDA Receptors of Gastric-Projecting Neurons in the Dorsal Motor Nucleus of the Vagus Mediate the Regulation of Gastric Emptying by EA at Weishu (BL21)
title_fullStr NMDA Receptors of Gastric-Projecting Neurons in the Dorsal Motor Nucleus of the Vagus Mediate the Regulation of Gastric Emptying by EA at Weishu (BL21)
title_full_unstemmed NMDA Receptors of Gastric-Projecting Neurons in the Dorsal Motor Nucleus of the Vagus Mediate the Regulation of Gastric Emptying by EA at Weishu (BL21)
title_sort nmda receptors of gastric-projecting neurons in the dorsal motor nucleus of the vagus mediate the regulation of gastric emptying by ea at weishu (bl21)
publisher Hindawi Limited
series Evidence-Based Complementary and Alternative Medicine
issn 1741-427X
1741-4288
publishDate 2012-01-01
description A large number of studies have been conducted to explore the efficacy of electroacupuncture (EA) for the treatment of gastrointestinal motility. While several lines of evidence addressed the basic mechanism of EA on gastrointestinal motility regarding effects of limb and abdomen points, the mechanism for effects of the back points on gastric motility still remains unclear. Here we report that the NMDA receptor (NMDAR) antagonist kynurenic acid inhibited the gastric emptying increase induced by high-intensity EA at BL21 and agonist NMDA enhanced the effect of the same treatment. EA at BL21 enhanced NMDAR, but not AMPA receptor (AMPAR) component of miniature excitatory postsynaptic current (mEPSC) in gastric-projecting neurons of the dorsal motor nucleus of the vagus (DMV). In sum, our data demonstrate an important role of NMDAR-mediated synaptic transmission of gastric-projecting DMV neurons in mediating EA at BL21-induced enhancement of gastric emptying.
url http://dx.doi.org/10.1155/2012/583479
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