T cell ignorance is bliss: T cells are not tolerized by Langerhans cells presenting human papillomavirus antigens in the absence of costimulation

T cell ignorance is bliss: T cells are not tolerized by Langerhans cells presenting human papillomavirus antigens in the absence of costimulation

Human papillomavirus type 16 (HPV16) infections are intra-epithelial, and thus, HPV16 is known to interact with Langerhans cells (LCs), the resident epithelial antigen-presenting cells (APCs). The current paradigm for APC-mediated induction of T cell anergy is through delivery of T cell receptor sig...

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Bibliographic Details
Main Authors: Andrew W. Woodham, Lisa Yan, Joseph G. Skeate, Daniel van der Veen, Heike E. Brand, Michael K. Wong, Diane M. Da Silva, W. Martin Kast
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:Papillomavirus Research
Online Access:http://www.sciencedirect.com/science/article/pii/S2405852115300069

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