Neoadjuvant chemotherapy regimens in treatment of breast cancer: a systematic review and network meta-analysis protocol
Abstract Background Neoadjuvant chemotherapy (NACT), a standard of care for locally advanced breast cancer patients, is widely used for early breast cancer patients also. The varying role of regimens used as NACT needs to be investigated. Despite availability of some randomized controlled trials (RC...
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doaj-bdf13473ea48477f89d4f9204570c4b42020-11-24T20:53:36ZengBMCSystematic Reviews2046-40532018-06-01711810.1186/s13643-018-0754-1Neoadjuvant chemotherapy regimens in treatment of breast cancer: a systematic review and network meta-analysis protocolMona Pathak0Sada Nand Dwivedi1S. V. S. Deo2Bhaskar Thakur3Vishnubhatla Sreenivas4G. K. Rath5Department of Biostatistics, All India Institute of Medical SciencesDepartment of Biostatistics, All India Institute of Medical SciencesDepartment of Surgical Oncology, Dr. BRA IRCH, All India Institute of Medical SciencesDepartment of Biostatistics, All India Institute of Medical SciencesDepartment of Biostatistics, All India Institute of Medical SciencesDepartment of Radiotherapy, Dr. BRA IRCH, All India Institute of Medical SciencesAbstract Background Neoadjuvant chemotherapy (NACT), a standard of care for locally advanced breast cancer patients, is widely used for early breast cancer patients also. The varying role of regimens used as NACT needs to be investigated. Despite availability of some randomized controlled trials (RCTs), it is unclear which treatment regimen suits best. Further, there is no study comparing all the three regimens. Accordingly, present study will compare the efficacy of anthracyclines, taxanes, and targeted therapy administered in neoadjuvant setting on the basis of oncological outcomes and functional outcomes. Method/design Online databases PubMed and Cochrane Register of Controlled Trials will be searched to acquire eligible studies. Further, content of relevant journals, references of relevant articles, and proceedings of major related conference will also be searched. The RCTs comparing any of abovementioned regimen as NACT on breast cancer patients will be eligible. Two reviewers independently and in duplicate will screen the records on the basis of title and abstract and complete full-text review to determine eligibility. Similarly, data extraction and risk of bias assessment will be done by two independent reviewers. The pair-wise meta-analysis as well as network meta-analysis will be conducted to assess the relative efficacy of anthracyclines, taxanes, and targeted therapy regimens. Discussion The present systematic review will improve the understanding of the relative efficacies of the three treatment regimens and possibly guide the clinical practices by providing the current best evidence on the efficacy of various regimens of NACT in the management of breast cancer patients. Systematic review registration PROSPERO (CRD42016027236).http://link.springer.com/article/10.1186/s13643-018-0754-1AnthracyclineTaxaneTrastuzumabBevacizumabNetwork meta-analysisBreast cancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mona Pathak Sada Nand Dwivedi S. V. S. Deo Bhaskar Thakur Vishnubhatla Sreenivas G. K. Rath |
spellingShingle |
Mona Pathak Sada Nand Dwivedi S. V. S. Deo Bhaskar Thakur Vishnubhatla Sreenivas G. K. Rath Neoadjuvant chemotherapy regimens in treatment of breast cancer: a systematic review and network meta-analysis protocol Systematic Reviews Anthracycline Taxane Trastuzumab Bevacizumab Network meta-analysis Breast cancer |
author_facet |
Mona Pathak Sada Nand Dwivedi S. V. S. Deo Bhaskar Thakur Vishnubhatla Sreenivas G. K. Rath |
author_sort |
Mona Pathak |
title |
Neoadjuvant chemotherapy regimens in treatment of breast cancer: a systematic review and network meta-analysis protocol |
title_short |
Neoadjuvant chemotherapy regimens in treatment of breast cancer: a systematic review and network meta-analysis protocol |
title_full |
Neoadjuvant chemotherapy regimens in treatment of breast cancer: a systematic review and network meta-analysis protocol |
title_fullStr |
Neoadjuvant chemotherapy regimens in treatment of breast cancer: a systematic review and network meta-analysis protocol |
title_full_unstemmed |
Neoadjuvant chemotherapy regimens in treatment of breast cancer: a systematic review and network meta-analysis protocol |
title_sort |
neoadjuvant chemotherapy regimens in treatment of breast cancer: a systematic review and network meta-analysis protocol |
publisher |
BMC |
series |
Systematic Reviews |
issn |
2046-4053 |
publishDate |
2018-06-01 |
description |
Abstract Background Neoadjuvant chemotherapy (NACT), a standard of care for locally advanced breast cancer patients, is widely used for early breast cancer patients also. The varying role of regimens used as NACT needs to be investigated. Despite availability of some randomized controlled trials (RCTs), it is unclear which treatment regimen suits best. Further, there is no study comparing all the three regimens. Accordingly, present study will compare the efficacy of anthracyclines, taxanes, and targeted therapy administered in neoadjuvant setting on the basis of oncological outcomes and functional outcomes. Method/design Online databases PubMed and Cochrane Register of Controlled Trials will be searched to acquire eligible studies. Further, content of relevant journals, references of relevant articles, and proceedings of major related conference will also be searched. The RCTs comparing any of abovementioned regimen as NACT on breast cancer patients will be eligible. Two reviewers independently and in duplicate will screen the records on the basis of title and abstract and complete full-text review to determine eligibility. Similarly, data extraction and risk of bias assessment will be done by two independent reviewers. The pair-wise meta-analysis as well as network meta-analysis will be conducted to assess the relative efficacy of anthracyclines, taxanes, and targeted therapy regimens. Discussion The present systematic review will improve the understanding of the relative efficacies of the three treatment regimens and possibly guide the clinical practices by providing the current best evidence on the efficacy of various regimens of NACT in the management of breast cancer patients. Systematic review registration PROSPERO (CRD42016027236). |
topic |
Anthracycline Taxane Trastuzumab Bevacizumab Network meta-analysis Breast cancer |
url |
http://link.springer.com/article/10.1186/s13643-018-0754-1 |
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