mRNA Structural constraints on EBNA1 synthesis impact on in vivo antigen presentation and early priming of CD8+ T cells.
Recent studies have shown that virally encoded mRNA sequences of genome maintenance proteins from herpesviruses contain clusters of unusual structural elements, G-quadruplexes, which modulate viral protein synthesis. Destabilization of these G-quadruplexes can override the inhibitory effect on self-...
Main Authors: | Judy T Tellam, Jie Zhong, Lea Lekieffre, Purnima Bhat, Michelle Martinez, Nathan P Croft, Warren Kaplan, Ross L Tellam, Rajiv Khanna |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-10-01
|
Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC4192603?pdf=render |
Similar Items
-
Messenger RNA sequence rather than protein sequence determines the level of self-synthesis and antigen presentation of the EBV-encoded antigen, EBNA1.
by: Judy T Tellam, et al.
Published: (2012-12-01) -
Epstein-Barr virus associated modulation of Wnt pathway is not dependent on latent membrane protein-1.
by: Natasha Webb, et al.
Published: (2008-09-01) -
Deregulation of the cell cycle by EBV nuclear antigens EBNA3A and EBNA3C
by: Skalska, Lenka
Published: (2012) -
The Epstein-Barr virus nuclear antigen (EBNA) complex
by: Allday, Martin John
Published: (1989) -
Structure and function of the Epstein-Barr virus nuclear antigen EBNA-1
by: Horner, David Stephen
Published: (1995)