Regulation of CHK1 by mTOR contributes to the evasion of DNA damage barrier of cancer cells

Regulation of CHK1 by mTOR contributes to the evasion of DNA damage barrier of cancer cells

Abstract Oncogenic transformation leads to dysregulated cell proliferation, nutrient deficiency, and hypoxia resulting in metabolic stress and increased DNA damage. In normal cells, such metabolic stress leads to inhibition of signaling through the mammalian Target of Rapamycin Complex 1 (mTORC1), r...

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Bibliographic Details
Main Authors: Xinhui Zhou, Weijin Liu, Xing Hu, Adrienne Dorrance, Ramiro Garzon, Peter J. Houghton, Changxian Shen
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-01729-w

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https://doi.org/10.1038/s41598-017-01729-w

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