Loss of an Androgen-Inactivating and Isoform-Specific HSD17B4 Splice Form Enables Emergence of Castration-Resistant Prostate Cancer

Loss of an Androgen-Inactivating and Isoform-Specific HSD17B4 Splice Form Enables Emergence of Castration-Resistant Prostate Cancer

Castration-resistant prostate cancer (CRPC) requires tumors to engage metabolic mechanisms that allow sustained testosterone and/or dihydrotestosterone to stimulate progression. 17β-Hydroxysteroid dehydrogenase type 4 (17βHSD4), encoded by HSD17B4, is thought to inactivate testosterone and dihydrote...

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Bibliographic Details
Main Authors: Hyun-Kyung Ko, Michael Berk, Yoon-Mi Chung, Belinda Willard, Rohan Bareja, Mark Rubin, Andrea Sboner, Nima Sharifi
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Cell Reports
Subjects:
prostate cancer
metabolism
androgens
androgen receptor
steroids
enzymes
drug resistance
HSD17B4
oncology
splicing
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717319186

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