A nineteen-year report of serotype and antimicrobial susceptibility of enteric non-typhoidal Salmonella from humans in Southern India: changing facades of taxonomy and resistance trend
Abstract Background The steady increase in the proportion of Non-typhoidal Salmonella (NTS) infections in humans represents a major health problem worldwide. The current study investigated the serovar distribution and antimicrobial susceptibility trends of NTS isolated from faecal samples during the...
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doaj-bdf74da9b9a94a98b04ce0db34d6ffc32020-11-25T03:56:34ZengBMCGut Pathogens1757-47492020-10-011211910.1186/s13099-020-00388-zA nineteen-year report of serotype and antimicrobial susceptibility of enteric non-typhoidal Salmonella from humans in Southern India: changing facades of taxonomy and resistance trendJobin John Jacob0Dhanalakshmi Solaimalai1Dhiviya Prabaa Muthuirulandi Sethuvel2Tanya Rachel3Praveena Jeslin4Shalini Anandan5Balaji Veeraraghavan6Department of Clinical Microbiology, Christian Medical College and HospitalDepartment of Clinical Microbiology, Christian Medical College and HospitalDepartment of Clinical Microbiology, Christian Medical College and HospitalDepartment of Clinical Microbiology, Christian Medical College and HospitalDepartment of Clinical Microbiology, Christian Medical College and HospitalDepartment of Clinical Microbiology, Christian Medical College and HospitalDepartment of Clinical Microbiology, Christian Medical College and HospitalAbstract Background The steady increase in the proportion of Non-typhoidal Salmonella (NTS) infections in humans represents a major health problem worldwide. The current study investigated the serovar distribution and antimicrobial susceptibility trends of NTS isolated from faecal samples during the period 2000–2018. Methods Faecal specimens of patients were cultured according to standard lab protocol. The isolates were serotyped and antimicrobial susceptibility testing (AST) were performed according to CLSI guidelines. Results A total of 1436 NTS isolates were obtained from faeces samples mostly comprising of S. Typhimurium (27.3%), S. Weltevreden (13%), S. Bareilly (11%), S. Newport (4.2%), S. Cholerasuis (4%), S. Infantis (3.4%), and S. Enteritidis (2.4%). Resistance to nalidixic acid (26%) was most common among the tested NTS, followed by ampicillin (18.5%), cotrimoxazole (13.5%), ciprofloxacin (12%), ceftriaxone (6.3%) and chloramphenicol (3.6%). Multidrug resistance was observed in 5% of NTS isolates with the highest rate (10.52%) in 2014. The incidence of NTS infection was maximum in children < 5 years of age with an average 19.3% of the total affected patients during the time period. Conclusions Based on this study, the faecal NTS isolates have high resistance rates against first line antimicrobial agents except chloramphenicol. The gradual but consistent increase in resistance to fluoroquinolones, third generation cephalosporins and macrolide may restrict future treatment options. Hence periodic monitoring of NTS infections, serotype distribution and antimicrobial resistance trend is recommended.http://link.springer.com/article/10.1186/s13099-020-00388-zNon-typhoidal SalmonellaMultidrug resistanceSurveillanceSerovar |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jobin John Jacob Dhanalakshmi Solaimalai Dhiviya Prabaa Muthuirulandi Sethuvel Tanya Rachel Praveena Jeslin Shalini Anandan Balaji Veeraraghavan |
spellingShingle |
Jobin John Jacob Dhanalakshmi Solaimalai Dhiviya Prabaa Muthuirulandi Sethuvel Tanya Rachel Praveena Jeslin Shalini Anandan Balaji Veeraraghavan A nineteen-year report of serotype and antimicrobial susceptibility of enteric non-typhoidal Salmonella from humans in Southern India: changing facades of taxonomy and resistance trend Gut Pathogens Non-typhoidal Salmonella Multidrug resistance Surveillance Serovar |
author_facet |
Jobin John Jacob Dhanalakshmi Solaimalai Dhiviya Prabaa Muthuirulandi Sethuvel Tanya Rachel Praveena Jeslin Shalini Anandan Balaji Veeraraghavan |
author_sort |
Jobin John Jacob |
title |
A nineteen-year report of serotype and antimicrobial susceptibility of enteric non-typhoidal Salmonella from humans in Southern India: changing facades of taxonomy and resistance trend |
title_short |
A nineteen-year report of serotype and antimicrobial susceptibility of enteric non-typhoidal Salmonella from humans in Southern India: changing facades of taxonomy and resistance trend |
title_full |
A nineteen-year report of serotype and antimicrobial susceptibility of enteric non-typhoidal Salmonella from humans in Southern India: changing facades of taxonomy and resistance trend |
title_fullStr |
A nineteen-year report of serotype and antimicrobial susceptibility of enteric non-typhoidal Salmonella from humans in Southern India: changing facades of taxonomy and resistance trend |
title_full_unstemmed |
A nineteen-year report of serotype and antimicrobial susceptibility of enteric non-typhoidal Salmonella from humans in Southern India: changing facades of taxonomy and resistance trend |
title_sort |
nineteen-year report of serotype and antimicrobial susceptibility of enteric non-typhoidal salmonella from humans in southern india: changing facades of taxonomy and resistance trend |
publisher |
BMC |
series |
Gut Pathogens |
issn |
1757-4749 |
publishDate |
2020-10-01 |
description |
Abstract Background The steady increase in the proportion of Non-typhoidal Salmonella (NTS) infections in humans represents a major health problem worldwide. The current study investigated the serovar distribution and antimicrobial susceptibility trends of NTS isolated from faecal samples during the period 2000–2018. Methods Faecal specimens of patients were cultured according to standard lab protocol. The isolates were serotyped and antimicrobial susceptibility testing (AST) were performed according to CLSI guidelines. Results A total of 1436 NTS isolates were obtained from faeces samples mostly comprising of S. Typhimurium (27.3%), S. Weltevreden (13%), S. Bareilly (11%), S. Newport (4.2%), S. Cholerasuis (4%), S. Infantis (3.4%), and S. Enteritidis (2.4%). Resistance to nalidixic acid (26%) was most common among the tested NTS, followed by ampicillin (18.5%), cotrimoxazole (13.5%), ciprofloxacin (12%), ceftriaxone (6.3%) and chloramphenicol (3.6%). Multidrug resistance was observed in 5% of NTS isolates with the highest rate (10.52%) in 2014. The incidence of NTS infection was maximum in children < 5 years of age with an average 19.3% of the total affected patients during the time period. Conclusions Based on this study, the faecal NTS isolates have high resistance rates against first line antimicrobial agents except chloramphenicol. The gradual but consistent increase in resistance to fluoroquinolones, third generation cephalosporins and macrolide may restrict future treatment options. Hence periodic monitoring of NTS infections, serotype distribution and antimicrobial resistance trend is recommended. |
topic |
Non-typhoidal Salmonella Multidrug resistance Surveillance Serovar |
url |
http://link.springer.com/article/10.1186/s13099-020-00388-z |
work_keys_str_mv |
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