Association of NAFLD and Insulin Resistance with Non Metastatic Bladder Cancer Patients: A Cross-Sectional Retrospective Study
Among risk factors (apart from smoking) likely involved in bladder cancer (BCa), metabolic syndrome (MS), obesity and type 2 diabetes mellitus (T2DM) have been explored with contrasting results. In spite of these studies, there is little data on the association between nonalcoholic fatty liver disea...
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doaj-bdfa6192136d4981b5cceab8dc9526eb2021-01-19T00:03:07ZengMDPI AGJournal of Clinical Medicine2077-03832021-01-011034634610.3390/jcm10020346Association of NAFLD and Insulin Resistance with Non Metastatic Bladder Cancer Patients: A Cross-Sectional Retrospective StudyGiovanni Tarantino0Felice Crocetto1Concetta Di Vito2Massimiliano Creta3Raffaele Martino4Savio Domenico Pandolfo5Salvatore Pesce6Luigi Napolitano7Domenico Capone8Ciro Imbimbo9Department of Clinical Medicine and Surgery, Federico II Medical School, Via S. Pansini 5, 80131 Naples, ItalyDepartment of Neuroscience, Reproductive Sciences and Dentistry, University of Naples “Federico II”, Via S. Pansini 5, 80131 Naples, ItalyDepartment of Neuroscience, Reproductive Sciences and Dentistry, University of Naples “Federico II”, Via S. Pansini 5, 80131 Naples, ItalyDepartment of Neuroscience, Reproductive Sciences and Dentistry, University of Naples “Federico II”, Via S. Pansini 5, 80131 Naples, ItalyDepartment of Neuroscience, Reproductive Sciences and Dentistry, University of Naples “Federico II”, Via S. Pansini 5, 80131 Naples, ItalyDepartment of Neuroscience, Reproductive Sciences and Dentistry, University of Naples “Federico II”, Via S. Pansini 5, 80131 Naples, ItalyDepartment of Neuroscience, Reproductive Sciences and Dentistry, University of Naples “Federico II”, Via S. Pansini 5, 80131 Naples, ItalyDepartment of Neuroscience, Reproductive Sciences and Dentistry, University of Naples “Federico II”, Via S. Pansini 5, 80131 Naples, ItalyClinical Pharmacology Consultant, Via Volturno 27, 80026 Casoria, Naples, ItalyDepartment of Neuroscience, Reproductive Sciences and Dentistry, University of Naples “Federico II”, Via S. Pansini 5, 80131 Naples, ItalyAmong risk factors (apart from smoking) likely involved in bladder cancer (BCa), metabolic syndrome (MS), obesity and type 2 diabetes mellitus (T2DM) have been explored with contrasting results. In spite of these studies, there is little data on the association between nonalcoholic fatty liver disease (NAFLD), its main driver, i.e., insulin resistance (IR), and BCa. Implanting a cross-sectional retrospective study we tried to investigate both NAFLD and IR prevalence in a hospital based population of BCa patients. We studied laboratory data from 204 patients with histologically confirmed non metastatic BCa and 50 subjects with no BCa, but with bladder diseases (no Ca BD). We evaluated the presence of NAFLD by the triglycerides/glucose Index (TyG Index), using a cut-off of 0.59 and by the Aspartate Aminotransferase/Alanine Aminotransferase AST/ALT ratio. IR was assessed by the same TyG Index (cut-off 4.68) and the triglycerides/High-Density Lipoprotein HDL ratio (cut-off 2.197). The diagnosis of impaired fasting glucose (IFG), condition of prediabetes, as well as that of T2DM was assessed according to canonical guidelines. The TyG Index predicted NAFLD presence in both groups (<i>p</i> = 0.000), but the BCa group showed a major percentage of NAFLD cases with respect to no Ca BD group (59% versus 40%). A greater proportion of IR (47%) in BCa group than in no Ca BD one (37%) was evidenced by the TyG Index with its median value significantly different (<i>p</i> = 0.0092). This high rate of IR in the BCa group was confirmed by the triglycerides/HDL ratio (<i>p</i> = 0.02). Prediabetes and T2DM were more prevalent in the BCa group than no Ca BD group (<i>p</i> = 0.024). In this study a consistent NAFLD presence was found in BCa patients. This is an important comorbidity factor that deserves further consideration in prospective studies. The higher prevalence of NAFLD, IR, prediabetes and T2DM in the BCa group evidences the need that these disorders should be reckoned as adjunct factors that could impact on this cancerous disease.https://www.mdpi.com/2077-0383/10/2/346bladder cancerno cancerous bladder diseasesNAFLDinsulin resistanceimpaired fasting glucoseprediabetes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Giovanni Tarantino Felice Crocetto Concetta Di Vito Massimiliano Creta Raffaele Martino Savio Domenico Pandolfo Salvatore Pesce Luigi Napolitano Domenico Capone Ciro Imbimbo |
spellingShingle |
Giovanni Tarantino Felice Crocetto Concetta Di Vito Massimiliano Creta Raffaele Martino Savio Domenico Pandolfo Salvatore Pesce Luigi Napolitano Domenico Capone Ciro Imbimbo Association of NAFLD and Insulin Resistance with Non Metastatic Bladder Cancer Patients: A Cross-Sectional Retrospective Study Journal of Clinical Medicine bladder cancer no cancerous bladder diseases NAFLD insulin resistance impaired fasting glucose prediabetes |
author_facet |
Giovanni Tarantino Felice Crocetto Concetta Di Vito Massimiliano Creta Raffaele Martino Savio Domenico Pandolfo Salvatore Pesce Luigi Napolitano Domenico Capone Ciro Imbimbo |
author_sort |
Giovanni Tarantino |
title |
Association of NAFLD and Insulin Resistance with Non Metastatic Bladder Cancer Patients: A Cross-Sectional Retrospective Study |
title_short |
Association of NAFLD and Insulin Resistance with Non Metastatic Bladder Cancer Patients: A Cross-Sectional Retrospective Study |
title_full |
Association of NAFLD and Insulin Resistance with Non Metastatic Bladder Cancer Patients: A Cross-Sectional Retrospective Study |
title_fullStr |
Association of NAFLD and Insulin Resistance with Non Metastatic Bladder Cancer Patients: A Cross-Sectional Retrospective Study |
title_full_unstemmed |
Association of NAFLD and Insulin Resistance with Non Metastatic Bladder Cancer Patients: A Cross-Sectional Retrospective Study |
title_sort |
association of nafld and insulin resistance with non metastatic bladder cancer patients: a cross-sectional retrospective study |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2021-01-01 |
description |
Among risk factors (apart from smoking) likely involved in bladder cancer (BCa), metabolic syndrome (MS), obesity and type 2 diabetes mellitus (T2DM) have been explored with contrasting results. In spite of these studies, there is little data on the association between nonalcoholic fatty liver disease (NAFLD), its main driver, i.e., insulin resistance (IR), and BCa. Implanting a cross-sectional retrospective study we tried to investigate both NAFLD and IR prevalence in a hospital based population of BCa patients. We studied laboratory data from 204 patients with histologically confirmed non metastatic BCa and 50 subjects with no BCa, but with bladder diseases (no Ca BD). We evaluated the presence of NAFLD by the triglycerides/glucose Index (TyG Index), using a cut-off of 0.59 and by the Aspartate Aminotransferase/Alanine Aminotransferase AST/ALT ratio. IR was assessed by the same TyG Index (cut-off 4.68) and the triglycerides/High-Density Lipoprotein HDL ratio (cut-off 2.197). The diagnosis of impaired fasting glucose (IFG), condition of prediabetes, as well as that of T2DM was assessed according to canonical guidelines. The TyG Index predicted NAFLD presence in both groups (<i>p</i> = 0.000), but the BCa group showed a major percentage of NAFLD cases with respect to no Ca BD group (59% versus 40%). A greater proportion of IR (47%) in BCa group than in no Ca BD one (37%) was evidenced by the TyG Index with its median value significantly different (<i>p</i> = 0.0092). This high rate of IR in the BCa group was confirmed by the triglycerides/HDL ratio (<i>p</i> = 0.02). Prediabetes and T2DM were more prevalent in the BCa group than no Ca BD group (<i>p</i> = 0.024). In this study a consistent NAFLD presence was found in BCa patients. This is an important comorbidity factor that deserves further consideration in prospective studies. The higher prevalence of NAFLD, IR, prediabetes and T2DM in the BCa group evidences the need that these disorders should be reckoned as adjunct factors that could impact on this cancerous disease. |
topic |
bladder cancer no cancerous bladder diseases NAFLD insulin resistance impaired fasting glucose prediabetes |
url |
https://www.mdpi.com/2077-0383/10/2/346 |
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