Cryo-EM structure and dynamics of the green-light absorbing proteorhodopsin

Cryo-EM structure and dynamics of the green-light absorbing proteorhodopsin

The cryo-EM structure of pentameric green-light absorbing proteorhodopsin together with molecular dynamics simulations and functional studies provides insights into the proton translocation pathway and oligomerization, and a protonation-dependent mechanism for intracellular half channel hydration.

Bibliographic Details
Main Authors: Stephan Hirschi, David Kalbermatter, Zöhre Ucurum, Thomas Lemmin, Dimitrios Fotiadis
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24429-6
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spelling doaj-be15953b5e8e49b3be8f4c74426e812d2021-07-11T11:43:15ZengNature Publishing GroupNature Communications2041-17232021-07-0112111010.1038/s41467-021-24429-6Cryo-EM structure and dynamics of the green-light absorbing proteorhodopsinStephan Hirschi0David Kalbermatter1Zöhre Ucurum2Thomas Lemmin3Dimitrios Fotiadis4Institute of Biochemistry and Molecular Medicine, University of BernInstitute of Biochemistry and Molecular Medicine, University of BernInstitute of Biochemistry and Molecular Medicine, University of BernDS3Lab, System Group, Department of Computer Sciences, ETH ZurichInstitute of Biochemistry and Molecular Medicine, University of BernThe cryo-EM structure of pentameric green-light absorbing proteorhodopsin together with molecular dynamics simulations and functional studies provides insights into the proton translocation pathway and oligomerization, and a protonation-dependent mechanism for intracellular half channel hydration.https://doi.org/10.1038/s41467-021-24429-6
collection DOAJ
language English
format Article
sources DOAJ
author Stephan Hirschi
David Kalbermatter
Zöhre Ucurum
Thomas Lemmin
Dimitrios Fotiadis
spellingShingle Stephan Hirschi
David Kalbermatter
Zöhre Ucurum
Thomas Lemmin
Dimitrios Fotiadis
Cryo-EM structure and dynamics of the green-light absorbing proteorhodopsin
Nature Communications
author_facet Stephan Hirschi
David Kalbermatter
Zöhre Ucurum
Thomas Lemmin
Dimitrios Fotiadis
author_sort Stephan Hirschi
title Cryo-EM structure and dynamics of the green-light absorbing proteorhodopsin
title_short Cryo-EM structure and dynamics of the green-light absorbing proteorhodopsin
title_full Cryo-EM structure and dynamics of the green-light absorbing proteorhodopsin
title_fullStr Cryo-EM structure and dynamics of the green-light absorbing proteorhodopsin
title_full_unstemmed Cryo-EM structure and dynamics of the green-light absorbing proteorhodopsin
title_sort cryo-em structure and dynamics of the green-light absorbing proteorhodopsin
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-07-01
description The cryo-EM structure of pentameric green-light absorbing proteorhodopsin together with molecular dynamics simulations and functional studies provides insights into the proton translocation pathway and oligomerization, and a protonation-dependent mechanism for intracellular half channel hydration.
url https://doi.org/10.1038/s41467-021-24429-6
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AT davidkalbermatter cryoemstructureanddynamicsofthegreenlightabsorbingproteorhodopsin
AT zohreucurum cryoemstructureanddynamicsofthegreenlightabsorbingproteorhodopsin
AT thomaslemmin cryoemstructureanddynamicsofthegreenlightabsorbingproteorhodopsin
AT dimitriosfotiadis cryoemstructureanddynamicsofthegreenlightabsorbingproteorhodopsin
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