Interferon Regulatory Factor 5 (<i>IRF5</i>) Gene Haplotypes Are Associated with Premature Coronary Artery Disease Association of the <i>IRF5</i> Polymorphisms with Cardiometabolic Parameters the Genetics of Atherosclerotic Disease (GEA) Mexican Study
Interferon regulatory factor 5 (<i>IRF5</i>) has an important role in the inflammatory process, a fundamental component of coronary artery disease (CAD). Thus, the objective of this study was to evaluate the association of <i>IRF5</i> polymorphisms with the development of pre...
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doaj-be15c1de53884cf6a5ab026a49b2ec0f2021-03-18T00:00:49ZengMDPI AGBiomolecules2218-273X2021-03-011144344310.3390/biom11030443Interferon Regulatory Factor 5 (<i>IRF5</i>) Gene Haplotypes Are Associated with Premature Coronary Artery Disease Association of the <i>IRF5</i> Polymorphisms with Cardiometabolic Parameters the Genetics of Atherosclerotic Disease (GEA) Mexican StudyRosalinda Posadas-Sánchez0Guillermo Cardoso-Saldaña1José Manuel Fragoso2Gilberto Vargas-Alarcón3Department of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, 14080 Mexico City, MexicoDepartment of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, 14080 Mexico City, MexicoDepartment of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, 14080 Mexico City, MexicoDepartment of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, 14080 Mexico City, MexicoInterferon regulatory factor 5 (<i>IRF5</i>) has an important role in the inflammatory process, a fundamental component of coronary artery disease (CAD). Thus, the objective of this study was to evaluate the association of <i>IRF5</i> polymorphisms with the development of premature CAD (pCAD) and cardiometabolic parameters. <i>IRF5</i> polymorphisms (rs1874330, rs3778754, rs3757386, rs3757385, rs3807134, rs3807135, and rs6968563) were determined in 1116 pCAD patients and 1003 controls. Polymorphism distribution was similar in patients and controls; however, the haplotype analysis showed five haplotypes with a different distribution. <i>TGCGTCT</i> (OR (odds ratio) = 1.248, <i>p</i> = 0005) and <i>TCTGCCT</i> (OR = 10.73, <i>p</i> < 0.0001) were associated with a high risk, whereas <i>TCCGTCT</i> (OR = 0.155, <i>p</i> < 0.0001), <i>CGCTTTT</i> (OR = 0.108, <i>p</i> < 0.0001), and <i>TCCGCCT</i> (OR = 0.014, <i>p</i> < 0.0001) were associated with a low risk of pCAD. Associations with aspartate aminotransferase, hypertriglyceridemia, magnesium deficiency, triglycerides/HDL-C index, LDL-C, and adiponectin levels were observed in pCAD patients. In controls, associations with hypoalphalipoproteinemia, non-HDL-C, apolipoprotein B, hyperuricemia, TNF-α, IL-6, IL-15, valvular calcification, and subclinical hypothyroidism were observed. In summary, five haplotypes were associated with pCAD, two with high risk and three with low risk. Some <i>IRF5</i> polymorphisms were associated with cardiometabolic parameters in pCAD patients and control.https://www.mdpi.com/2218-273X/11/3/443cardiometabolic parametersgenetic associationinterferon regulatory factor 5polymorphismspremature coronary artery disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rosalinda Posadas-Sánchez Guillermo Cardoso-Saldaña José Manuel Fragoso Gilberto Vargas-Alarcón |
spellingShingle |
Rosalinda Posadas-Sánchez Guillermo Cardoso-Saldaña José Manuel Fragoso Gilberto Vargas-Alarcón Interferon Regulatory Factor 5 (<i>IRF5</i>) Gene Haplotypes Are Associated with Premature Coronary Artery Disease Association of the <i>IRF5</i> Polymorphisms with Cardiometabolic Parameters the Genetics of Atherosclerotic Disease (GEA) Mexican Study Biomolecules cardiometabolic parameters genetic association interferon regulatory factor 5 polymorphisms premature coronary artery disease |
author_facet |
Rosalinda Posadas-Sánchez Guillermo Cardoso-Saldaña José Manuel Fragoso Gilberto Vargas-Alarcón |
author_sort |
Rosalinda Posadas-Sánchez |
title |
Interferon Regulatory Factor 5 (<i>IRF5</i>) Gene Haplotypes Are Associated with Premature Coronary Artery Disease Association of the <i>IRF5</i> Polymorphisms with Cardiometabolic Parameters the Genetics of Atherosclerotic Disease (GEA) Mexican Study |
title_short |
Interferon Regulatory Factor 5 (<i>IRF5</i>) Gene Haplotypes Are Associated with Premature Coronary Artery Disease Association of the <i>IRF5</i> Polymorphisms with Cardiometabolic Parameters the Genetics of Atherosclerotic Disease (GEA) Mexican Study |
title_full |
Interferon Regulatory Factor 5 (<i>IRF5</i>) Gene Haplotypes Are Associated with Premature Coronary Artery Disease Association of the <i>IRF5</i> Polymorphisms with Cardiometabolic Parameters the Genetics of Atherosclerotic Disease (GEA) Mexican Study |
title_fullStr |
Interferon Regulatory Factor 5 (<i>IRF5</i>) Gene Haplotypes Are Associated with Premature Coronary Artery Disease Association of the <i>IRF5</i> Polymorphisms with Cardiometabolic Parameters the Genetics of Atherosclerotic Disease (GEA) Mexican Study |
title_full_unstemmed |
Interferon Regulatory Factor 5 (<i>IRF5</i>) Gene Haplotypes Are Associated with Premature Coronary Artery Disease Association of the <i>IRF5</i> Polymorphisms with Cardiometabolic Parameters the Genetics of Atherosclerotic Disease (GEA) Mexican Study |
title_sort |
interferon regulatory factor 5 (<i>irf5</i>) gene haplotypes are associated with premature coronary artery disease association of the <i>irf5</i> polymorphisms with cardiometabolic parameters the genetics of atherosclerotic disease (gea) mexican study |
publisher |
MDPI AG |
series |
Biomolecules |
issn |
2218-273X |
publishDate |
2021-03-01 |
description |
Interferon regulatory factor 5 (<i>IRF5</i>) has an important role in the inflammatory process, a fundamental component of coronary artery disease (CAD). Thus, the objective of this study was to evaluate the association of <i>IRF5</i> polymorphisms with the development of premature CAD (pCAD) and cardiometabolic parameters. <i>IRF5</i> polymorphisms (rs1874330, rs3778754, rs3757386, rs3757385, rs3807134, rs3807135, and rs6968563) were determined in 1116 pCAD patients and 1003 controls. Polymorphism distribution was similar in patients and controls; however, the haplotype analysis showed five haplotypes with a different distribution. <i>TGCGTCT</i> (OR (odds ratio) = 1.248, <i>p</i> = 0005) and <i>TCTGCCT</i> (OR = 10.73, <i>p</i> < 0.0001) were associated with a high risk, whereas <i>TCCGTCT</i> (OR = 0.155, <i>p</i> < 0.0001), <i>CGCTTTT</i> (OR = 0.108, <i>p</i> < 0.0001), and <i>TCCGCCT</i> (OR = 0.014, <i>p</i> < 0.0001) were associated with a low risk of pCAD. Associations with aspartate aminotransferase, hypertriglyceridemia, magnesium deficiency, triglycerides/HDL-C index, LDL-C, and adiponectin levels were observed in pCAD patients. In controls, associations with hypoalphalipoproteinemia, non-HDL-C, apolipoprotein B, hyperuricemia, TNF-α, IL-6, IL-15, valvular calcification, and subclinical hypothyroidism were observed. In summary, five haplotypes were associated with pCAD, two with high risk and three with low risk. Some <i>IRF5</i> polymorphisms were associated with cardiometabolic parameters in pCAD patients and control. |
topic |
cardiometabolic parameters genetic association interferon regulatory factor 5 polymorphisms premature coronary artery disease |
url |
https://www.mdpi.com/2218-273X/11/3/443 |
work_keys_str_mv |
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