Interferon Regulatory Factor 5 (<i>IRF5</i>) Gene Haplotypes Are Associated with Premature Coronary Artery Disease Association of the <i>IRF5</i> Polymorphisms with Cardiometabolic Parameters the Genetics of Atherosclerotic Disease (GEA) Mexican Study

• Main Authors: Rosalinda Posadas-Sánchez, Guillermo Cardoso-Saldaña, José Manuel Fragoso, Gilberto Vargas-Alarcón
• Format: Article
• Language: English
• Published: MDPI AG 2021-03-01
• Series: Biomolecules
• Subjects: cardiometabolic parameters; genetic association; interferon regulatory factor 5; polymorphisms; premature coronary artery disease
• Online Access: https://www.mdpi.com/2218-273X/11/3/443

Interferon regulatory factor 5 (<i>IRF5</i>) has an important role in the inflammatory process, a fundamental component of coronary artery disease (CAD). Thus, the objective of this study was to evaluate the association of <i>IRF5</i> polymorphisms with the development of premature CAD (pCAD) and cardiometabolic parameters. <i>IRF5</i> polymorphisms (rs1874330, rs3778754, rs3757386, rs3757385, rs3807134, rs3807135, and rs6968563) were determined in 1116 pCAD patients and 1003 controls. Polymorphism distribution was similar in patients and controls; however, the haplotype analysis showed five haplotypes with a different distribution. <i>TGCGTCT</i> (OR (odds ratio) = 1.248, <i>p</i> = 0005) and <i>TCTGCCT</i> (OR = 10.73, <i>p</i> < 0.0001) were associated with a high risk, whereas <i>TCCGTCT</i> (OR = 0.155, <i>p</i> < 0.0001), <i>CGCTTTT</i> (OR = 0.108, <i>p</i> < 0.0001), and <i>TCCGCCT</i> (OR = 0.014, <i>p</i> < 0.0001) were associated with a low risk of pCAD. Associations with aspartate aminotransferase, hypertriglyceridemia, magnesium deficiency, triglycerides/HDL-C index, LDL-C, and adiponectin levels were observed in pCAD patients. In controls, associations with hypoalphalipoproteinemia, non-HDL-C, apolipoprotein B, hyperuricemia, TNF-α, IL-6, IL-15, valvular calcification, and subclinical hypothyroidism were observed. In summary, five haplotypes were associated with pCAD, two with high risk and three with low risk. Some <i>IRF5</i> polymorphisms were associated with cardiometabolic parameters in pCAD patients and control.