Dengue, chikungunya, and scrub typhus are important etiologies of non-malarial febrile illness in Rourkela, Odisha, India
Abstract Background We conducted a diagnostic surveillance study to identify Plasmodium, dengue virus, chikungunya virus, and Orientia tsutsugamushi infections among febrile patients who underwent triage for malaria in the outpatient department at Ispat General Hospital, Rourkela, Odisha, India. Met...
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doaj-be19c821406d4713b03d467b2b72e9a02020-11-25T03:12:00ZengBMCBMC Infectious Diseases1471-23342019-07-0119111310.1186/s12879-019-4161-6Dengue, chikungunya, and scrub typhus are important etiologies of non-malarial febrile illness in Rourkela, Odisha, IndiaPavitra N. Rao0Anna Maria van Eijk1Sandhya Choubey2Syed Zeeshan Ali3Aditee Dash4Punam Barla5Rajshri Rani Oraon6Gautam Patel7P. Nandini8Subrata Acharya9Sanjib Mohanty10Jane M. Carlton11Sanghamitra Satpathi12Center for Genomics and Systems Biology, Department of Biology, New York UniversityCenter for Genomics and Systems Biology, Department of Biology, New York UniversityCenter for the Study of Complex Malaria in India, Ispat General HospitalCenter for the Study of Complex Malaria in India, Ispat General HospitalCenter for the Study of Complex Malaria in India, Ispat General HospitalCenter for the Study of Complex Malaria in India, Ispat General HospitalCenter for the Study of Complex Malaria in India, Ispat General HospitalCenter for the Study of Complex Malaria in India, Ispat General HospitalCenter for the Study of Complex Malaria in India, Ispat General HospitalCenter for the Study of Complex Malaria in India, Ispat General HospitalCenter for the Study of Complex Malaria in India, Ispat General HospitalCenter for Genomics and Systems Biology, Department of Biology, New York UniversityDepartment of Pathology, Ispat General Hospital RourkelaAbstract Background We conducted a diagnostic surveillance study to identify Plasmodium, dengue virus, chikungunya virus, and Orientia tsutsugamushi infections among febrile patients who underwent triage for malaria in the outpatient department at Ispat General Hospital, Rourkela, Odisha, India. Methods Febrile patients were enrolled from January 2016–January 2017. Blood smears and small volumes or vacutainers of blood were collected from study participants to carry out diagnostic assays. Malaria was diagnosed using rapid diagnostic tests (RDT), microscopy, and PCR. Dengue, chikungunya, and scrub typhus infections were identified using rapid diagnostic test kits and ELISA. Results Nine hundred and fifty-four patients were prospectively enrolled in our study. The majority of patients were male (58.4%) and more than 15 years of age (66.4%). All 954 enrollees underwent additional testing for malaria; a subset of enrollees (293/954) that had larger volumes of plasma available was also tested for dengue, chikungunya and scrub typhus by either RDT or ELISA or both tests. Fifty-four of 954 patients (5.7%) were positive for malaria by RDT, or microscopy, or PCR. Seventy-four of 293 patients (25.3%) tested positive for dengue by either RDT or ELISA, and 17 of 293 patients (5.8%) tested positive for chikungunya-specific IgM by either ELISA or RDT. Ten of 287 patients tested (3.5%) were positive for scrub typhus by ELISA specific for scrub typhus IgM. Seventeen patients among 290 (5.9%) with results for ≥3 infections tested positive for more than one infection. Patients with scrub typhus and chikungunya had high rates of co-infection: of the 10 patients positive for scrub typhus, six were positive for dengue (p = 0.009), and five of 17 patients positive for chikungunya (by RDT or ELISA) were also diagnosed with malaria (p < 0.001). Conclusions Dengue, chikungunya and scrub typhus are important etiologies of non-malarial febrile illness in Rourkela, Odisha, and comorbidity should be considered. Routine febrile illness surveillance is required to accurately establish the prevalence of these infections in this region, to offer timely treatment, and to implement appropriate methods of control.http://link.springer.com/article/10.1186/s12879-019-4161-6Febrile illnessMalariaDengueChikungunyaScrub typhusIndia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pavitra N. Rao Anna Maria van Eijk Sandhya Choubey Syed Zeeshan Ali Aditee Dash Punam Barla Rajshri Rani Oraon Gautam Patel P. Nandini Subrata Acharya Sanjib Mohanty Jane M. Carlton Sanghamitra Satpathi |
spellingShingle |
Pavitra N. Rao Anna Maria van Eijk Sandhya Choubey Syed Zeeshan Ali Aditee Dash Punam Barla Rajshri Rani Oraon Gautam Patel P. Nandini Subrata Acharya Sanjib Mohanty Jane M. Carlton Sanghamitra Satpathi Dengue, chikungunya, and scrub typhus are important etiologies of non-malarial febrile illness in Rourkela, Odisha, India BMC Infectious Diseases Febrile illness Malaria Dengue Chikungunya Scrub typhus India |
author_facet |
Pavitra N. Rao Anna Maria van Eijk Sandhya Choubey Syed Zeeshan Ali Aditee Dash Punam Barla Rajshri Rani Oraon Gautam Patel P. Nandini Subrata Acharya Sanjib Mohanty Jane M. Carlton Sanghamitra Satpathi |
author_sort |
Pavitra N. Rao |
title |
Dengue, chikungunya, and scrub typhus are important etiologies of non-malarial febrile illness in Rourkela, Odisha, India |
title_short |
Dengue, chikungunya, and scrub typhus are important etiologies of non-malarial febrile illness in Rourkela, Odisha, India |
title_full |
Dengue, chikungunya, and scrub typhus are important etiologies of non-malarial febrile illness in Rourkela, Odisha, India |
title_fullStr |
Dengue, chikungunya, and scrub typhus are important etiologies of non-malarial febrile illness in Rourkela, Odisha, India |
title_full_unstemmed |
Dengue, chikungunya, and scrub typhus are important etiologies of non-malarial febrile illness in Rourkela, Odisha, India |
title_sort |
dengue, chikungunya, and scrub typhus are important etiologies of non-malarial febrile illness in rourkela, odisha, india |
publisher |
BMC |
series |
BMC Infectious Diseases |
issn |
1471-2334 |
publishDate |
2019-07-01 |
description |
Abstract Background We conducted a diagnostic surveillance study to identify Plasmodium, dengue virus, chikungunya virus, and Orientia tsutsugamushi infections among febrile patients who underwent triage for malaria in the outpatient department at Ispat General Hospital, Rourkela, Odisha, India. Methods Febrile patients were enrolled from January 2016–January 2017. Blood smears and small volumes or vacutainers of blood were collected from study participants to carry out diagnostic assays. Malaria was diagnosed using rapid diagnostic tests (RDT), microscopy, and PCR. Dengue, chikungunya, and scrub typhus infections were identified using rapid diagnostic test kits and ELISA. Results Nine hundred and fifty-four patients were prospectively enrolled in our study. The majority of patients were male (58.4%) and more than 15 years of age (66.4%). All 954 enrollees underwent additional testing for malaria; a subset of enrollees (293/954) that had larger volumes of plasma available was also tested for dengue, chikungunya and scrub typhus by either RDT or ELISA or both tests. Fifty-four of 954 patients (5.7%) were positive for malaria by RDT, or microscopy, or PCR. Seventy-four of 293 patients (25.3%) tested positive for dengue by either RDT or ELISA, and 17 of 293 patients (5.8%) tested positive for chikungunya-specific IgM by either ELISA or RDT. Ten of 287 patients tested (3.5%) were positive for scrub typhus by ELISA specific for scrub typhus IgM. Seventeen patients among 290 (5.9%) with results for ≥3 infections tested positive for more than one infection. Patients with scrub typhus and chikungunya had high rates of co-infection: of the 10 patients positive for scrub typhus, six were positive for dengue (p = 0.009), and five of 17 patients positive for chikungunya (by RDT or ELISA) were also diagnosed with malaria (p < 0.001). Conclusions Dengue, chikungunya and scrub typhus are important etiologies of non-malarial febrile illness in Rourkela, Odisha, and comorbidity should be considered. Routine febrile illness surveillance is required to accurately establish the prevalence of these infections in this region, to offer timely treatment, and to implement appropriate methods of control. |
topic |
Febrile illness Malaria Dengue Chikungunya Scrub typhus India |
url |
http://link.springer.com/article/10.1186/s12879-019-4161-6 |
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