Discovery of EMRE in fungi resolves the true evolutionary history of the mitochondrial calcium uniporter

Discovery of EMRE in fungi resolves the true evolutionary history of the mitochondrial calcium uniporter

The mitochondrial calcium uptake system, crucial for cellular processes, evolved in ancient eukaryotes. Here, authors perform a phylogenomic analysis across 1,156 eukaryotes, and show that previously identified animal and fungal genes in this system originated from an ancestral duplication.

Bibliographic Details
Main Authors: Alexandros A. Pittis, Valerie Goh, Alberto Cebrian-Serrano, Jennifer Wettmarshausen, Fabiana Perocchi, Toni Gabaldón
Format: Article
Language:English
Published: Nature Publishing Group 2020-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17705-4
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spelling doaj-be276a83a522423db2f562d273d11d582021-08-15T11:41:30ZengNature Publishing GroupNature Communications2041-17232020-08-0111111010.1038/s41467-020-17705-4Discovery of EMRE in fungi resolves the true evolutionary history of the mitochondrial calcium uniporterAlexandros A. Pittis0Valerie Goh1Alberto Cebrian-Serrano2Jennifer Wettmarshausen3Fabiana Perocchi4Toni Gabaldón5Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and TechnologyInstitute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum MünchenInstitute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum MünchenInstitute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum MünchenInstitute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum MünchenCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and TechnologyThe mitochondrial calcium uptake system, crucial for cellular processes, evolved in ancient eukaryotes. Here, authors perform a phylogenomic analysis across 1,156 eukaryotes, and show that previously identified animal and fungal genes in this system originated from an ancestral duplication.https://doi.org/10.1038/s41467-020-17705-4
collection DOAJ
language English
format Article
sources DOAJ
author Alexandros A. Pittis
Valerie Goh
Alberto Cebrian-Serrano
Jennifer Wettmarshausen
Fabiana Perocchi
Toni Gabaldón
spellingShingle Alexandros A. Pittis
Valerie Goh
Alberto Cebrian-Serrano
Jennifer Wettmarshausen
Fabiana Perocchi
Toni Gabaldón
Discovery of EMRE in fungi resolves the true evolutionary history of the mitochondrial calcium uniporter
Nature Communications
author_facet Alexandros A. Pittis
Valerie Goh
Alberto Cebrian-Serrano
Jennifer Wettmarshausen
Fabiana Perocchi
Toni Gabaldón
author_sort Alexandros A. Pittis
title Discovery of EMRE in fungi resolves the true evolutionary history of the mitochondrial calcium uniporter
title_short Discovery of EMRE in fungi resolves the true evolutionary history of the mitochondrial calcium uniporter
title_full Discovery of EMRE in fungi resolves the true evolutionary history of the mitochondrial calcium uniporter
title_fullStr Discovery of EMRE in fungi resolves the true evolutionary history of the mitochondrial calcium uniporter
title_full_unstemmed Discovery of EMRE in fungi resolves the true evolutionary history of the mitochondrial calcium uniporter
title_sort discovery of emre in fungi resolves the true evolutionary history of the mitochondrial calcium uniporter
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-08-01
description The mitochondrial calcium uptake system, crucial for cellular processes, evolved in ancient eukaryotes. Here, authors perform a phylogenomic analysis across 1,156 eukaryotes, and show that previously identified animal and fungal genes in this system originated from an ancestral duplication.
url https://doi.org/10.1038/s41467-020-17705-4
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AT valeriegoh discoveryofemreinfungiresolvesthetrueevolutionaryhistoryofthemitochondrialcalciumuniporter
AT albertocebrianserrano discoveryofemreinfungiresolvesthetrueevolutionaryhistoryofthemitochondrialcalciumuniporter
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AT fabianaperocchi discoveryofemreinfungiresolvesthetrueevolutionaryhistoryofthemitochondrialcalciumuniporter
AT tonigabaldon discoveryofemreinfungiresolvesthetrueevolutionaryhistoryofthemitochondrialcalciumuniporter
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