Oncostatin M Mediates Adipocyte Expression and Secretion of Stromal-Derived Factor 1

• Main Authors: Hardy Hang, Jennifer L. Bailey, Carrie M. Elks
• Format: Article
• Language: English
• Published: MDPI AG 2019-03-01
• Series: Biology
• Subjects: oncostatin M; adipose tissue; stromal-derived factor 1; adipocyte; inflammation
• Online Access: https://www.mdpi.com/2079-7737/8/1/19

Adipose tissue homeostasis depends on interactions between stromal cells, adipocytes, and the cytokines and chemokines they produce. The gp130 cytokine, oncostatin M (OSM), plays a role in adipose tissue homeostasis. Mice, lacking the OSM receptor (OSMR) in adipocytes (<i>Osmr</i>^FKO mice), exhibit derangements in adipose tissue, insulin sensitivity, and immune cell balance. Here, we describe a possible role for the chemokine stromal-derived factor 1 (SDF-1) in these alterations. We treated 3T3-L1 adipocytes with OSM and observed a suppression of SDF-1 gene expression and protein secretion, an effect which was partially blunted by OSMR knockdown. However, <i>Osmr</i>^FKO mice also exhibited decreased SDF-1 gene and protein expression in adipose tissue. These contrasting results suggest that the loss of adipocyte OSM&#8211;OSMR signaling in vivo may be indirectly affecting adipokine production and secretion by altering OSM target genes to ultimately decrease SDF-1 expression in the <i>Osmr</i>^FKO mouse. We conclude that adipocyte OSM&#8211;OSMR signaling plays a role in adipose tissue SDF-1 production and may mitigate its effects on adipose tissue homeostasis.