Hit-to-lead development of the chamigrane endoperoxide merulin A for the treatment of African sleeping sickness.

Hit-to-lead development of the chamigrane endoperoxide merulin A for the treatment of African sleeping sickness.

Human African trypanosomiasis (HAT) is an infectious disease with a large global health burden occurring primarily in Central and Eastern Africa. Most current treatments have poor blood brain barrier (BBB) penetration, which prevent them from targeting the most lethal stage of the infection. In addi...

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Bibliographic Details
Main Authors: Gabriel Navarro, Supchar Chokpaiboon, Geraldine De Muylder, Walter M Bray, Sean C Nisam, James H McKerrow, Khanitha Pudhom, Roger G Linington
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3459870?pdf=render

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http://europepmc.org/articles/PMC3459870?pdf=render

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