A prospective observational study with dose volume parameters predicting rectosigmoidoscopic findings and late rectosigmoid bleeding in patients with uterine cervical cancer treated by definitive radiotherapy
<p>Abstract</p> <p>Purpose</p> <p>We assessed the value of dose-volumetric parameters predicting rectosigmoid mucosal changes (RMC) and late rectosigmoid complications (LRC).</p> <p>Methods</p> <p>Between January 2004 and February 2006, 77 patien...
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BMC
2013-01-01
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| Series: | Radiation Oncology |
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| Online Access: | http://www.ro-journal.com/content/8/1/28 |
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doaj-be35c8a9bf2b4d219833f68234cc742d2020-11-24T20:44:16ZengBMCRadiation Oncology1748-717X2013-01-01812810.1186/1748-717X-8-28A prospective observational study with dose volume parameters predicting rectosigmoidoscopic findings and late rectosigmoid bleeding in patients with uterine cervical cancer treated by definitive radiotherapyKim Tae HyunKim Joo-YoungSohn Dae KyungKim Yeon-JooLee Yoon-SeokMoon Sung HoKim Sang SooKim Dae Yong<p>Abstract</p> <p>Purpose</p> <p>We assessed the value of dose-volumetric parameters predicting rectosigmoid mucosal changes (RMC) and late rectosigmoid complications (LRC).</p> <p>Methods</p> <p>Between January 2004 and February 2006, 77 patients with stage IB-IIIB cervical cancer underwent external beam radiotherapy and computed tomography (CT)-based intracavitary irradiation. Total dose to the rectal point and several dose-volumetric parameters for rectosigmoid colon (D<sub>20cc</sub>, D<sub>15cc</sub>, D<sub>10cc</sub>, D<sub>5cc</sub>, D<sub>2cc</sub>, D<sub>1cc</sub>, and D<sub>0.1cc ,</sub> defined as the minimal doses received by the highest irradiated volumes of 20, 15, 10, 5, 2, 1, and 0.1 cc, respectively), were calculated using the equivalent dose in 2 Gy fractions (α/β = 3, Gy<sub>3</sub>). The RMC and LRC were graded by rectosigmoidoscopy and Radiation Therapy Oncology Group criteria every 6 months, respectively.</p> <p>Results</p> <p>Of 77 patients, 27 (35.1%) patients developed RMC ≥ score 3 and 22 (28.6 %) patients developed LRC ≥ grade 2. There was a positive correlation between RMC score and LRC grade (<it>r</it> = 0.728, <it>p</it> < 0.001). In multivariate analyses, D<sub>5cc</sub>, among the dose-volumetric parameters, was significant parameter for the risks of RMC ≥ score 3 and LRC ≥ grade 2 (<it>p <</it> 0.05).</p> <p>Conclusions</p> <p>D<sub>5cc</sub> may be a more reliable estimate than other dose-volumetric parameters for predicting the risk of RMC ≥ score 3 and LRC ≥ grade 2 in CT-based brachytherapy.</p> http://www.ro-journal.com/content/8/1/28Dose-volumetric parametersRectosigmoid mucosal changeLate rectosigmoid complicationUterine cervical cancer |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Kim Tae Hyun Kim Joo-Young Sohn Dae Kyung Kim Yeon-Joo Lee Yoon-Seok Moon Sung Ho Kim Sang Soo Kim Dae Yong |
| spellingShingle |
Kim Tae Hyun Kim Joo-Young Sohn Dae Kyung Kim Yeon-Joo Lee Yoon-Seok Moon Sung Ho Kim Sang Soo Kim Dae Yong A prospective observational study with dose volume parameters predicting rectosigmoidoscopic findings and late rectosigmoid bleeding in patients with uterine cervical cancer treated by definitive radiotherapy Radiation Oncology Dose-volumetric parameters Rectosigmoid mucosal change Late rectosigmoid complication Uterine cervical cancer |
| author_facet |
Kim Tae Hyun Kim Joo-Young Sohn Dae Kyung Kim Yeon-Joo Lee Yoon-Seok Moon Sung Ho Kim Sang Soo Kim Dae Yong |
| author_sort |
Kim Tae Hyun |
| title |
A prospective observational study with dose volume parameters predicting rectosigmoidoscopic findings and late rectosigmoid bleeding in patients with uterine cervical cancer treated by definitive radiotherapy |
| title_short |
A prospective observational study with dose volume parameters predicting rectosigmoidoscopic findings and late rectosigmoid bleeding in patients with uterine cervical cancer treated by definitive radiotherapy |
| title_full |
A prospective observational study with dose volume parameters predicting rectosigmoidoscopic findings and late rectosigmoid bleeding in patients with uterine cervical cancer treated by definitive radiotherapy |
| title_fullStr |
A prospective observational study with dose volume parameters predicting rectosigmoidoscopic findings and late rectosigmoid bleeding in patients with uterine cervical cancer treated by definitive radiotherapy |
| title_full_unstemmed |
A prospective observational study with dose volume parameters predicting rectosigmoidoscopic findings and late rectosigmoid bleeding in patients with uterine cervical cancer treated by definitive radiotherapy |
| title_sort |
prospective observational study with dose volume parameters predicting rectosigmoidoscopic findings and late rectosigmoid bleeding in patients with uterine cervical cancer treated by definitive radiotherapy |
| publisher |
BMC |
| series |
Radiation Oncology |
| issn |
1748-717X |
| publishDate |
2013-01-01 |
| description |
<p>Abstract</p> <p>Purpose</p> <p>We assessed the value of dose-volumetric parameters predicting rectosigmoid mucosal changes (RMC) and late rectosigmoid complications (LRC).</p> <p>Methods</p> <p>Between January 2004 and February 2006, 77 patients with stage IB-IIIB cervical cancer underwent external beam radiotherapy and computed tomography (CT)-based intracavitary irradiation. Total dose to the rectal point and several dose-volumetric parameters for rectosigmoid colon (D<sub>20cc</sub>, D<sub>15cc</sub>, D<sub>10cc</sub>, D<sub>5cc</sub>, D<sub>2cc</sub>, D<sub>1cc</sub>, and D<sub>0.1cc ,</sub> defined as the minimal doses received by the highest irradiated volumes of 20, 15, 10, 5, 2, 1, and 0.1 cc, respectively), were calculated using the equivalent dose in 2 Gy fractions (α/β = 3, Gy<sub>3</sub>). The RMC and LRC were graded by rectosigmoidoscopy and Radiation Therapy Oncology Group criteria every 6 months, respectively.</p> <p>Results</p> <p>Of 77 patients, 27 (35.1%) patients developed RMC ≥ score 3 and 22 (28.6 %) patients developed LRC ≥ grade 2. There was a positive correlation between RMC score and LRC grade (<it>r</it> = 0.728, <it>p</it> < 0.001). In multivariate analyses, D<sub>5cc</sub>, among the dose-volumetric parameters, was significant parameter for the risks of RMC ≥ score 3 and LRC ≥ grade 2 (<it>p <</it> 0.05).</p> <p>Conclusions</p> <p>D<sub>5cc</sub> may be a more reliable estimate than other dose-volumetric parameters for predicting the risk of RMC ≥ score 3 and LRC ≥ grade 2 in CT-based brachytherapy.</p> |
| topic |
Dose-volumetric parameters Rectosigmoid mucosal change Late rectosigmoid complication Uterine cervical cancer |
| url |
http://www.ro-journal.com/content/8/1/28 |
| work_keys_str_mv |
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