Direct conversion of human fibroblasts to functional excitatory cortical neurons integrating into human neural networks

Direct conversion of human fibroblasts to functional excitatory cortical neurons integrating into human neural networks

Abstract Background Human fibroblasts can be directly converted to several subtypes of neurons, but cortical projection neurons have not been generated. Methods Here we screened for transcription factor combinations that could potentially convert human fibroblasts to functional excitatory cortical n...

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Bibliographic Details
Main Authors: Giedre Miskinyte, Karthikeyan Devaraju, Marita Grønning Hansen, Emanuela Monni, Daniel Tornero, Niels Bjarne Woods, Johan Bengzon, Henrik Ahlenius, Olle Lindvall, Zaal Kokaia
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Stem Cell Research & Therapy
Subjects:
Cortical projection neurons
Direct conversion
Human adult cortical slices
Human fibroblasts
Online Access:http://link.springer.com/article/10.1186/s13287-017-0658-3

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