Radiologic Modalities and Response Assessment Schemes for Clinical and Preclinical Oncology Imaging

• Main Authors: Farshid Faraji, Ron C. Gaba
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2019-06-01
• Series: Frontiers in Oncology
• Subjects: Radiology; imaging; trial; standards; large animal model
• Online Access: https://www.frontiersin.org/article/10.3389/fonc.2019.00471/full

Clinical drug trials for oncology have resulted in universal protocols for medical imaging in order to standardize protocols for image procurement, radiologic interpretation, and therapeutic response assessment. In recent years, there has been increasing interest in using large animal models to study oncologic disease, though few standards currently exist for imaging of large animal models. This article briefly reviews medical imaging modalities, the current state-of-the-art in radiologic diagnostic criteria and response assessment schemes for evaluating therapeutic response and disease progression, and translation of radiologic imaging protocols and standards to large animal models of malignant disease.