A Septin Cytoskeleton-Targeting Small Molecule, Forchlorfenuron, Inhibits Epithelial Migration via Septin-Independent Perturbation of Cellular Signaling

A Septin Cytoskeleton-Targeting Small Molecule, Forchlorfenuron, Inhibits Epithelial Migration via Septin-Independent Perturbation of Cellular Signaling

Septins are GTP-binding proteins that self-assemble into high-order cytoskeletal structures, filaments, and rings. The septin cytoskeleton has a number of cellular functions, including regulation of cytokinesis, cell migration, vesicle trafficking, and receptor signaling. A plant cytokinin, forchlor...

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Bibliographic Details
Main Authors: Lei Sun, Xuelei Cao, Susana Lechuga, Alex Feygin, Nayden G. Naydenov, Andrei I. Ivanov
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:Cells
Subjects:
septin cytoskeleton
epithelial cells
migration
wound healing
hepatocyte growth factor
epithelial barrier
off-target effects
Online Access:https://www.mdpi.com/2073-4409/9/1/84

Internet

https://www.mdpi.com/2073-4409/9/1/84

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