Minimal Sex-Differential Modulation of Reactivity to Pathogens and Toll-Like Receptor Ligands following Infant Bacillus Calmette–Guérin Russia Vaccination

Minimal Sex-Differential Modulation of Reactivity to Pathogens and Toll-Like Receptor Ligands following Infant Bacillus Calmette–Guérin Russia Vaccination

Bacillus Calmette–Guérin (BCG), the only licensed vaccine against tuberculosis, has been shown to provide heterologous protection against unrelated pathogens and enhance antibody responses to several routine expanded program on immunization (EPI) vaccines. Understanding these heterologous effects is...

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Bibliographic Details
Main Authors: Fatoumatta Darboe, Jane U. Adetifa, John Reynolds, Safayet Hossin, Magdalena Plebanski, Mihai G. Netea, Sarah L. Rowland-Jones, Jayne S. Sutherland, Katie L. Flanagan
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Immunology
Subjects:
vaccine
toll-like receptors
non-specific effects
heterologous effects
cytokines
innate immunity
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01092/full

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