Synthesis and in vitro antimicrobial evaluation of 5-amino-7-aryl-6-cyano-4H- pyrano[3,2,b]pyrrole derivatives catalyzed by reusable ZrOCl2•8H2O
An efficient synthesis of a new series of 5-amino-7-aryl-6-cyano-4H-pyrano[3,2-b]pyrrole derivatives from the reaction of 3-hydroxypyrrole, malononitrile, and various aromatic aldehydes using ZrOCl2·8H2O, an environmentally friendly catalyst under a thermal solvent-free green procedure is described....
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Chemical Society of Ethiopia
2014-01-01
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| Series: | Bulletin of the Chemical Society of Ethiopia |
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| Online Access: | http://www.ajol.info/index.php/bcse/article/view/100117 |
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doaj-be5248dc275044a08da3a5491743767c2020-11-24T23:44:18ZengChemical Society of EthiopiaBulletin of the Chemical Society of Ethiopia1011-39241726-801X2014-01-012819110010.4314/bcse.v28i1.11Synthesis and in vitro antimicrobial evaluation of 5-amino-7-aryl-6-cyano-4H- pyrano[3,2,b]pyrrole derivatives catalyzed by reusable ZrOCl2•8H2OA. Mohammed HussainS. Sheik MansoorK. AswinK. LogaiyaS. P.N. SudhanAn efficient synthesis of a new series of 5-amino-7-aryl-6-cyano-4H-pyrano[3,2-b]pyrrole derivatives from the reaction of 3-hydroxypyrrole, malononitrile, and various aromatic aldehydes using ZrOCl2·8H2O, an environmentally friendly catalyst under a thermal solvent-free green procedure is described. This simple protocol offer advantages such as shorter reaction times, simple work-up and excellent yield. The catalyst ZrOCl2·8H2O can be reused. The reusability of the catalyst has been studied for the synthesis of 5-amino-7-aryl-6-cyano-4H-pyrano[3,2-b]pyrrole. All the compounds were screened for their antibacterial and antifungal activity. DOI:http://dx.doi.org/10.4314/bcse.v28i1.11http://www.ajol.info/index.php/bcse/article/view/100117ZrOCl2·8H2OPyranopyrroleMalononitrile3-HydroxypyrroleSolvent-free |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
A. Mohammed Hussain S. Sheik Mansoor K. Aswin K. Logaiya S. P.N. Sudhan |
| spellingShingle |
A. Mohammed Hussain S. Sheik Mansoor K. Aswin K. Logaiya S. P.N. Sudhan Synthesis and in vitro antimicrobial evaluation of 5-amino-7-aryl-6-cyano-4H- pyrano[3,2,b]pyrrole derivatives catalyzed by reusable ZrOCl2•8H2O Bulletin of the Chemical Society of Ethiopia ZrOCl2·8H2O Pyranopyrrole Malononitrile 3-Hydroxypyrrole Solvent-free |
| author_facet |
A. Mohammed Hussain S. Sheik Mansoor K. Aswin K. Logaiya S. P.N. Sudhan |
| author_sort |
A. Mohammed Hussain |
| title |
Synthesis and in vitro antimicrobial evaluation of 5-amino-7-aryl-6-cyano-4H- pyrano[3,2,b]pyrrole derivatives catalyzed by reusable ZrOCl2•8H2O |
| title_short |
Synthesis and in vitro antimicrobial evaluation of 5-amino-7-aryl-6-cyano-4H- pyrano[3,2,b]pyrrole derivatives catalyzed by reusable ZrOCl2•8H2O |
| title_full |
Synthesis and in vitro antimicrobial evaluation of 5-amino-7-aryl-6-cyano-4H- pyrano[3,2,b]pyrrole derivatives catalyzed by reusable ZrOCl2•8H2O |
| title_fullStr |
Synthesis and in vitro antimicrobial evaluation of 5-amino-7-aryl-6-cyano-4H- pyrano[3,2,b]pyrrole derivatives catalyzed by reusable ZrOCl2•8H2O |
| title_full_unstemmed |
Synthesis and in vitro antimicrobial evaluation of 5-amino-7-aryl-6-cyano-4H- pyrano[3,2,b]pyrrole derivatives catalyzed by reusable ZrOCl2•8H2O |
| title_sort |
synthesis and in vitro antimicrobial evaluation of 5-amino-7-aryl-6-cyano-4h- pyrano[3,2,b]pyrrole derivatives catalyzed by reusable zrocl2•8h2o |
| publisher |
Chemical Society of Ethiopia |
| series |
Bulletin of the Chemical Society of Ethiopia |
| issn |
1011-3924 1726-801X |
| publishDate |
2014-01-01 |
| description |
An efficient synthesis of a new series of 5-amino-7-aryl-6-cyano-4H-pyrano[3,2-b]pyrrole derivatives from the reaction of 3-hydroxypyrrole, malononitrile, and various aromatic aldehydes using ZrOCl2·8H2O, an environmentally friendly catalyst under a thermal solvent-free green procedure is described. This simple protocol offer advantages such as shorter reaction times, simple work-up and excellent yield. The catalyst ZrOCl2·8H2O can be reused. The reusability of the catalyst has been studied for the synthesis of 5-amino-7-aryl-6-cyano-4H-pyrano[3,2-b]pyrrole. All the compounds were screened for their antibacterial and antifungal activity. DOI:http://dx.doi.org/10.4314/bcse.v28i1.11 |
| topic |
ZrOCl2·8H2O Pyranopyrrole Malononitrile 3-Hydroxypyrrole Solvent-free |
| url |
http://www.ajol.info/index.php/bcse/article/view/100117 |
| work_keys_str_mv |
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