Comparative lipid and uric acid suppressing properties of four common herbs in high fat-induced obese mice with their total phenolic and flavonoid index
Our present study was designed to investigate the comparative anti-obesity efficacy of ethanolic extract of Azadirachta indica A. Juss., Trigonella foenum-graecum L., Allium sativum L. and Zingiber officinale Roscoe in high fat-induced mice with their total phenolic and flavonoid profile. Total phen...
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doaj-be531a67f8754c1cbfdc9193a0d0151b2021-06-05T06:09:53ZengElsevierBiochemistry and Biophysics Reports2405-58082021-07-0126100990Comparative lipid and uric acid suppressing properties of four common herbs in high fat-induced obese mice with their total phenolic and flavonoid indexTanoy Mazumder0Imran Parvez Mamun1Md. Safayat Zaman2A.K.M. Khairul Islam3Shahjalal Chowdhury4Md. Sharif Reza5Md. Saddam Hussain6Faculty of Science, Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, BangladeshFaculty of Science, Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, BangladeshFaculty of Science, Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, BangladeshFaculty of Science, Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, BangladeshFaculty of Science, Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, BangladeshFaculty of Science, Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, BangladeshCorresponding author.; Faculty of Science, Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, BangladeshOur present study was designed to investigate the comparative anti-obesity efficacy of ethanolic extract of Azadirachta indica A. Juss., Trigonella foenum-graecum L., Allium sativum L. and Zingiber officinale Roscoe in high fat-induced mice with their total phenolic and flavonoid profile. Total phenolic and flavonoid content were determined by Folin–Ciocalteu's and Aluminium chloride UV method respectively. In our study, 55 healthy mice were separated into 11 groups to take their respective treatments. Lipid and uric acid profile were estimated by using the enzymatic colourimetric method. Ethanolic extract of A. indica contained the highest phenolic and flavonoid content. A. indica normal and high fat diet group showed reduced weight gaining tendency than other extract groups. A. indica at a dose of 400 mg/kg body weight significantly (p < 0.001) reduced serum cholesterol (SC), triglyceride (TG), and uric acid (UA) level than other three extracts when compared with the control group. Thus, a considerable correlation was found between serum uric acid reducing potentials of the present experimental extracts with a lipid-lowering profile. Pathological examination revealed that the average weight of liver and kidney were significantly decreased in A. indica normal. Results obtained from the present study it can be concluded that ethanolic extract of A. indica possesses better lipid-lowering efficacy than the other three herbs.http://www.sciencedirect.com/science/article/pii/S2405580821000844Lipid-loweringPhenolic and flavonoid contentCholesterolTriglycerideUric acidCardiovascular drugs |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tanoy Mazumder Imran Parvez Mamun Md. Safayat Zaman A.K.M. Khairul Islam Shahjalal Chowdhury Md. Sharif Reza Md. Saddam Hussain |
spellingShingle |
Tanoy Mazumder Imran Parvez Mamun Md. Safayat Zaman A.K.M. Khairul Islam Shahjalal Chowdhury Md. Sharif Reza Md. Saddam Hussain Comparative lipid and uric acid suppressing properties of four common herbs in high fat-induced obese mice with their total phenolic and flavonoid index Biochemistry and Biophysics Reports Lipid-lowering Phenolic and flavonoid content Cholesterol Triglyceride Uric acid Cardiovascular drugs |
author_facet |
Tanoy Mazumder Imran Parvez Mamun Md. Safayat Zaman A.K.M. Khairul Islam Shahjalal Chowdhury Md. Sharif Reza Md. Saddam Hussain |
author_sort |
Tanoy Mazumder |
title |
Comparative lipid and uric acid suppressing properties of four common herbs in high fat-induced obese mice with their total phenolic and flavonoid index |
title_short |
Comparative lipid and uric acid suppressing properties of four common herbs in high fat-induced obese mice with their total phenolic and flavonoid index |
title_full |
Comparative lipid and uric acid suppressing properties of four common herbs in high fat-induced obese mice with their total phenolic and flavonoid index |
title_fullStr |
Comparative lipid and uric acid suppressing properties of four common herbs in high fat-induced obese mice with their total phenolic and flavonoid index |
title_full_unstemmed |
Comparative lipid and uric acid suppressing properties of four common herbs in high fat-induced obese mice with their total phenolic and flavonoid index |
title_sort |
comparative lipid and uric acid suppressing properties of four common herbs in high fat-induced obese mice with their total phenolic and flavonoid index |
publisher |
Elsevier |
series |
Biochemistry and Biophysics Reports |
issn |
2405-5808 |
publishDate |
2021-07-01 |
description |
Our present study was designed to investigate the comparative anti-obesity efficacy of ethanolic extract of Azadirachta indica A. Juss., Trigonella foenum-graecum L., Allium sativum L. and Zingiber officinale Roscoe in high fat-induced mice with their total phenolic and flavonoid profile. Total phenolic and flavonoid content were determined by Folin–Ciocalteu's and Aluminium chloride UV method respectively. In our study, 55 healthy mice were separated into 11 groups to take their respective treatments. Lipid and uric acid profile were estimated by using the enzymatic colourimetric method. Ethanolic extract of A. indica contained the highest phenolic and flavonoid content. A. indica normal and high fat diet group showed reduced weight gaining tendency than other extract groups. A. indica at a dose of 400 mg/kg body weight significantly (p < 0.001) reduced serum cholesterol (SC), triglyceride (TG), and uric acid (UA) level than other three extracts when compared with the control group. Thus, a considerable correlation was found between serum uric acid reducing potentials of the present experimental extracts with a lipid-lowering profile. Pathological examination revealed that the average weight of liver and kidney were significantly decreased in A. indica normal. Results obtained from the present study it can be concluded that ethanolic extract of A. indica possesses better lipid-lowering efficacy than the other three herbs. |
topic |
Lipid-lowering Phenolic and flavonoid content Cholesterol Triglyceride Uric acid Cardiovascular drugs |
url |
http://www.sciencedirect.com/science/article/pii/S2405580821000844 |
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