Cholesterol and ApoE in Alzheimer’s disease
Genetic, neuropathological and biochemical studies suggest strong links between cholesterol, the apolipoprotein E (APOE) and Alzheimer’s disease (AD), both in humans and in animal models of the disease. From the literature and our work, we can predict that transient increase of the levels of cholest...
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2018-07-01
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Online Access: | https://doi.org/10.1051/ocl/2018038 |
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doaj-be53287a80754a1bae29192187ea07ab2021-02-02T07:53:36ZengEDP SciencesOilseeds and fats, crops and lipids2272-69772257-66142018-07-01254D40710.1051/ocl/2018038ocl180014Cholesterol and ApoE in Alzheimer’s diseasePotier Marie-ClaudeHanbouch LindaMarquer CatherineGenetic, neuropathological and biochemical studies suggest strong links between cholesterol, the apolipoprotein E (APOE) and Alzheimer’s disease (AD), both in humans and in animal models of the disease. From the literature and our work, we can predict that transient increase of the levels of cholesterol at the membrane of neurons would profoundly affect the processing of the transmembrane Amyloid Precursor Protein (APP) by triggering its clathrin dependent endocytosis and the resulting production of amyloid-β (Aβ) peptides. Here, we will review these data together with structural and molecular dynamic studies that characterized the role of cholesterol on APP conformation and positioning at the membrane. Specifically decreasing brain cholesterol or replacing it with plant sterols crossing the blood brain barrier appear like promising strategies to either delay or counteract the development of sporadic AD.https://doi.org/10.1051/ocl/2018038Alzheimer’s diseasecholesterolApo lipoprotein Eendosomeamyloid |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Potier Marie-Claude Hanbouch Linda Marquer Catherine |
spellingShingle |
Potier Marie-Claude Hanbouch Linda Marquer Catherine Cholesterol and ApoE in Alzheimer’s disease Oilseeds and fats, crops and lipids Alzheimer’s disease cholesterol Apo lipoprotein E endosome amyloid |
author_facet |
Potier Marie-Claude Hanbouch Linda Marquer Catherine |
author_sort |
Potier Marie-Claude |
title |
Cholesterol and ApoE in Alzheimer’s disease |
title_short |
Cholesterol and ApoE in Alzheimer’s disease |
title_full |
Cholesterol and ApoE in Alzheimer’s disease |
title_fullStr |
Cholesterol and ApoE in Alzheimer’s disease |
title_full_unstemmed |
Cholesterol and ApoE in Alzheimer’s disease |
title_sort |
cholesterol and apoe in alzheimer’s disease |
publisher |
EDP Sciences |
series |
Oilseeds and fats, crops and lipids |
issn |
2272-6977 2257-6614 |
publishDate |
2018-07-01 |
description |
Genetic, neuropathological and biochemical studies suggest strong links between cholesterol, the apolipoprotein E (APOE) and Alzheimer’s disease (AD), both in humans and in animal models of the disease. From the literature and our work, we can predict that transient increase of the levels of cholesterol at the membrane of neurons would profoundly affect the processing of the transmembrane Amyloid Precursor Protein (APP) by triggering its clathrin dependent endocytosis and the resulting production of amyloid-β (Aβ) peptides. Here, we will review these data together with structural and molecular dynamic studies that characterized the role of cholesterol on APP conformation and positioning at the membrane. Specifically decreasing brain cholesterol or replacing it with plant sterols crossing the blood brain barrier appear like promising strategies to either delay or counteract the development of sporadic AD. |
topic |
Alzheimer’s disease cholesterol Apo lipoprotein E endosome amyloid |
url |
https://doi.org/10.1051/ocl/2018038 |
work_keys_str_mv |
AT potiermarieclaude cholesterolandapoeinalzheimersdisease AT hanbouchlinda cholesterolandapoeinalzheimersdisease AT marquercatherine cholesterolandapoeinalzheimersdisease |
_version_ |
1724298458921172992 |