Real-Time Scintigraphic Assessment of Intravenous Radium-223 Administration for Quality Control
Radium-223 (223Ra) dichloride is an approved intravenous radiotherapy for patients with osseous metastases from castration-resistant prostate cancer (CRPC). In addition to the therapeutic alpha radiation, there is additional 223Ra radiation generated which produces photons that can be imaged with co...
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Online Access: | http://dx.doi.org/10.1155/2015/324708 |
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doaj-be566d9f5dfd4695bdd927fda464316b2020-11-24T23:48:41ZengHindawi LimitedBioMed Research International2314-61332314-61412015-01-01201510.1155/2015/324708324708Real-Time Scintigraphic Assessment of Intravenous Radium-223 Administration for Quality ControlChadwick L. Wright0J. Paul Monk1Douglas A. Murrey2Nathan C. Hall3Department of Radiology, The Ohio State University Wexner Medical Center, 410 West Tenth Avenue, Columbus, OH 43210, USADivision of Medical Oncology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, 410 West Tenth Avenue, Columbus, OH 43210, USADepartment of Radiology, The Ohio State University Wexner Medical Center, 410 West Tenth Avenue, Columbus, OH 43210, USADepartment of Radiology, The Ohio State University Wexner Medical Center, 410 West Tenth Avenue, Columbus, OH 43210, USARadium-223 (223Ra) dichloride is an approved intravenous radiotherapy for patients with osseous metastases from castration-resistant prostate cancer (CRPC). In addition to the therapeutic alpha radiation, there is additional 223Ra radiation generated which produces photons that can be imaged with conventional gamma cameras. No studies have evaluated real-time and quality imaging during intravenous 223Ra administration to verify systemic circulation and exclude 223Ra extravasation at the injection site. A retrospective review was performed for fifteen 223Ra administrations for CRPC patients which were imaged using a large field of view portable gamma camera (LFOVPGC) for the purposes of quality control and patient safety. Dynamic imaging of the chest was performed before, during, and after the 223Ra administration to verify systemic circulation, per institutional clinical protocol. Before and after 223Ra administration, a static image was obtained of the intravenous access site. Dynamic imaging of the chest confirmed systemic administration early during the 1-minute injection period for all patients. There were no cases of focal 223Ra extravasation at the site of intravenous access. These results verify that systemic 223Ra administrations can be quantified with real-time imaging using an LFOVPGC. This simple approach can confirm and quantify systemic circulation of 223Ra early during injection and exclude focal extravasation for the purposes of quality control.http://dx.doi.org/10.1155/2015/324708 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chadwick L. Wright J. Paul Monk Douglas A. Murrey Nathan C. Hall |
spellingShingle |
Chadwick L. Wright J. Paul Monk Douglas A. Murrey Nathan C. Hall Real-Time Scintigraphic Assessment of Intravenous Radium-223 Administration for Quality Control BioMed Research International |
author_facet |
Chadwick L. Wright J. Paul Monk Douglas A. Murrey Nathan C. Hall |
author_sort |
Chadwick L. Wright |
title |
Real-Time Scintigraphic Assessment of Intravenous Radium-223 Administration for Quality Control |
title_short |
Real-Time Scintigraphic Assessment of Intravenous Radium-223 Administration for Quality Control |
title_full |
Real-Time Scintigraphic Assessment of Intravenous Radium-223 Administration for Quality Control |
title_fullStr |
Real-Time Scintigraphic Assessment of Intravenous Radium-223 Administration for Quality Control |
title_full_unstemmed |
Real-Time Scintigraphic Assessment of Intravenous Radium-223 Administration for Quality Control |
title_sort |
real-time scintigraphic assessment of intravenous radium-223 administration for quality control |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2015-01-01 |
description |
Radium-223 (223Ra) dichloride is an approved intravenous radiotherapy for patients with osseous metastases from castration-resistant prostate cancer (CRPC). In addition to the therapeutic alpha radiation, there is additional 223Ra radiation generated which produces photons that can be imaged with conventional gamma cameras. No studies have evaluated real-time and quality imaging during intravenous 223Ra administration to verify systemic circulation and exclude 223Ra extravasation at the injection site. A retrospective review was performed for fifteen 223Ra administrations for CRPC patients which were imaged using a large field of view portable gamma camera (LFOVPGC) for the purposes of quality control and patient safety. Dynamic imaging of the chest was performed before, during, and after the 223Ra administration to verify systemic circulation, per institutional clinical protocol. Before and after 223Ra administration, a static image was obtained of the intravenous access site. Dynamic imaging of the chest confirmed systemic administration early during the 1-minute injection period for all patients. There were no cases of focal 223Ra extravasation at the site of intravenous access. These results verify that systemic 223Ra administrations can be quantified with real-time imaging using an LFOVPGC. This simple approach can confirm and quantify systemic circulation of 223Ra early during injection and exclude focal extravasation for the purposes of quality control. |
url |
http://dx.doi.org/10.1155/2015/324708 |
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