Environmental eustress modulates β-ARs/CCL2 axis to induce anti-tumor immunity and sensitize immunotherapy against liver cancer in mice

The impact of positive environment stimulations (eustress) on cancer biology remains poorly understood. Here the authors show that exposure to an environment enrichment stimulates anti-tumor immunity and reduces tumor growth in preclinical models of liver cancer.

Bibliographic Details
Main Authors:	Chaobao Liu, Yang Yang, Cheng Chen, Ling Li, Jingquan Li, Xiaonan Wang, Qiao Chu, Lin Qiu, Qian Ba, Xiaoguang Li, Hui Wang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-25967-9

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spelling	doaj-be5a062266a54b60a3d9d8b31385a8f82021-10-03T11:50:23ZengNature Publishing GroupNature Communications2041-17232021-09-0112111510.1038/s41467-021-25967-9Environmental eustress modulates β-ARs/CCL2 axis to induce anti-tumor immunity and sensitize immunotherapy against liver cancer in miceChaobao Liu0Yang Yang1Cheng Chen2Ling Li3Jingquan Li4Xiaonan Wang5Qiao Chu6Lin Qiu7Qian Ba8Xiaoguang Li9Hui Wang10State Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of MedicineState Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of MedicineState Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of MedicineState Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of MedicineState Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of MedicineState Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of MedicineState Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of MedicineCAS Key Laboratory of Nutrition, Metabolism and Food safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of SciencesState Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of MedicineState Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of MedicineState Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of MedicineThe impact of positive environment stimulations (eustress) on cancer biology remains poorly understood. Here the authors show that exposure to an environment enrichment stimulates anti-tumor immunity and reduces tumor growth in preclinical models of liver cancer.https://doi.org/10.1038/s41467-021-25967-9
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Chaobao Liu Yang Yang Cheng Chen Ling Li Jingquan Li Xiaonan Wang Qiao Chu Lin Qiu Qian Ba Xiaoguang Li Hui Wang
spellingShingle	Chaobao Liu Yang Yang Cheng Chen Ling Li Jingquan Li Xiaonan Wang Qiao Chu Lin Qiu Qian Ba Xiaoguang Li Hui Wang Environmental eustress modulates β-ARs/CCL2 axis to induce anti-tumor immunity and sensitize immunotherapy against liver cancer in mice Nature Communications
author_facet	Chaobao Liu Yang Yang Cheng Chen Ling Li Jingquan Li Xiaonan Wang Qiao Chu Lin Qiu Qian Ba Xiaoguang Li Hui Wang
author_sort	Chaobao Liu
title	Environmental eustress modulates β-ARs/CCL2 axis to induce anti-tumor immunity and sensitize immunotherapy against liver cancer in mice
title_short	Environmental eustress modulates β-ARs/CCL2 axis to induce anti-tumor immunity and sensitize immunotherapy against liver cancer in mice
title_full	Environmental eustress modulates β-ARs/CCL2 axis to induce anti-tumor immunity and sensitize immunotherapy against liver cancer in mice
title_fullStr	Environmental eustress modulates β-ARs/CCL2 axis to induce anti-tumor immunity and sensitize immunotherapy against liver cancer in mice
title_full_unstemmed	Environmental eustress modulates β-ARs/CCL2 axis to induce anti-tumor immunity and sensitize immunotherapy against liver cancer in mice
title_sort	environmental eustress modulates β-ars/ccl2 axis to induce anti-tumor immunity and sensitize immunotherapy against liver cancer in mice
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-09-01
description	The impact of positive environment stimulations (eustress) on cancer biology remains poorly understood. Here the authors show that exposure to an environment enrichment stimulates anti-tumor immunity and reduces tumor growth in preclinical models of liver cancer.
url	https://doi.org/10.1038/s41467-021-25967-9
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Environmental eustress modulates β-ARs/CCL2 axis to induce anti-tumor immunity and sensitize immunotherapy against liver cancer in mice

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