Serum anti-inflammatory cytokines for the evaluation of inflammatory status in endometriosis
Background: Endometriosis is a frequent gynecologic disease with a severe impact on the quality of life in the affected women; its pathogenesis is yet to be fully understood, with an altered immunity as a possible key factor. The present study aimed to investigate the serum anti-inflammatory cytokin...
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Wolters Kluwer Medknow Publications
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doaj-be5f6dde15fc47a1a2d99cb491e7ffa42020-11-24T23:28:44ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362015-01-0120766867410.4103/1735-1995.166215Serum anti-inflammatory cytokines for the evaluation of inflammatory status in endometriosisAndrei Mihai MalutanTudor DruganRăzvan CiorteaRadu Florin Mocan-HognogiCarmen BucuriMaria Patricia RadaDan MihuBackground: Endometriosis is a frequent gynecologic disease with a severe impact on the quality of life in the affected women; its pathogenesis is yet to be fully understood, with an altered immunity as a possible key factor. The present study aimed to investigate the serum anti-inflammatory cytokine profile in the patients with endometriosis compared with the healthy controls. Materials and Methods: One hundred and sixty women were included, divided into two study groups (Group I - endometriosis; Group 2 - healthy women). We evaluated the serum levels of interleukin-1 receptor antagonist (IL-1Ra), IL-2, IL-2R, IL-4, IL-10, IL-13, and IL-15 with the use of Human multiplex cytokine panels. Statistical analyses (normality distribution analysis, independent t-test, Mann-Whitney U-test) were performed using IBM SPSS software (version 22.0) and GraphPad Prism (version 5.00); receiver operating characteristic curve were used to demonstrate the diagnostic performance of the studied markers. Results: The mean serum level of IL-1Ra, IL-4, and IL-10 were significantly higher in women with endometriosis compared to women free of disease from the control group (30.155, 138.459, and 1.489, respectively, compared to 14.109, 84.710, and 0.688, respectively; P < 0.001, P < 0.001, and P = 0.002, respectively.). No significant differences in the mean serum levels of IL-2, IL-13, and IL-15 were observed between the studied groups and IL-2R had a very low detection rate. Conclusion: Endometriosis is associated with elevated levels of anti-inflammatory cytokines, IL-1Ra, IL-4, and IL-10, markers that have a potential role as a prognostic factor for endometriosis.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2015;volume=20;issue=7;spage=668;epage=674;aulast=MalutanCytokinesendometriosisimmunityinflammationinterleukin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Andrei Mihai Malutan Tudor Drugan Răzvan Ciortea Radu Florin Mocan-Hognogi Carmen Bucuri Maria Patricia Rada Dan Mihu |
spellingShingle |
Andrei Mihai Malutan Tudor Drugan Răzvan Ciortea Radu Florin Mocan-Hognogi Carmen Bucuri Maria Patricia Rada Dan Mihu Serum anti-inflammatory cytokines for the evaluation of inflammatory status in endometriosis Journal of Research in Medical Sciences Cytokines endometriosis immunity inflammation interleukin |
author_facet |
Andrei Mihai Malutan Tudor Drugan Răzvan Ciortea Radu Florin Mocan-Hognogi Carmen Bucuri Maria Patricia Rada Dan Mihu |
author_sort |
Andrei Mihai Malutan |
title |
Serum anti-inflammatory cytokines for the evaluation of inflammatory status in endometriosis |
title_short |
Serum anti-inflammatory cytokines for the evaluation of inflammatory status in endometriosis |
title_full |
Serum anti-inflammatory cytokines for the evaluation of inflammatory status in endometriosis |
title_fullStr |
Serum anti-inflammatory cytokines for the evaluation of inflammatory status in endometriosis |
title_full_unstemmed |
Serum anti-inflammatory cytokines for the evaluation of inflammatory status in endometriosis |
title_sort |
serum anti-inflammatory cytokines for the evaluation of inflammatory status in endometriosis |
publisher |
Wolters Kluwer Medknow Publications |
series |
Journal of Research in Medical Sciences |
issn |
1735-1995 1735-7136 |
publishDate |
2015-01-01 |
description |
Background: Endometriosis is a frequent gynecologic disease with a severe impact on the quality of life in the affected women; its pathogenesis is yet to be fully understood, with an altered immunity as a possible key factor. The present study aimed to investigate the serum anti-inflammatory cytokine profile in the patients with endometriosis compared with the healthy controls. Materials and Methods: One hundred and sixty women were included, divided into two study groups (Group I - endometriosis; Group 2 - healthy women). We evaluated the serum levels of interleukin-1 receptor antagonist (IL-1Ra), IL-2, IL-2R, IL-4, IL-10, IL-13, and IL-15 with the use of Human multiplex cytokine panels. Statistical analyses (normality distribution analysis, independent t-test, Mann-Whitney U-test) were performed using IBM SPSS software (version 22.0) and GraphPad Prism (version 5.00); receiver operating characteristic curve were used to demonstrate the diagnostic performance of the studied markers. Results: The mean serum level of IL-1Ra, IL-4, and IL-10 were significantly higher in women with endometriosis compared to women free of disease from the control group (30.155, 138.459, and 1.489, respectively, compared to 14.109, 84.710, and 0.688, respectively; P < 0.001, P < 0.001, and P = 0.002, respectively.). No significant differences in the mean serum levels of IL-2, IL-13, and IL-15 were observed between the studied groups and IL-2R had a very low detection rate. Conclusion: Endometriosis is associated with elevated levels of anti-inflammatory cytokines, IL-1Ra, IL-4, and IL-10, markers that have a potential role as a prognostic factor for endometriosis. |
topic |
Cytokines endometriosis immunity inflammation interleukin |
url |
http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2015;volume=20;issue=7;spage=668;epage=674;aulast=Malutan |
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