Striatum-Mediated Deficits in Stimulus-Response Learning and Decision-Making in OCD
Obsessive compulsive disorder (OCD) is a prevalent psychiatric disorder characterized by obsessions and compulsions. Studies investigating symptomatology and cognitive deficits in OCD frequently implicate the striatum. The aim of this study was to explore striatum-mediated cognitive deficits in pati...
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Frontiers Media S.A.
2020-02-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2020.00013/full |
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doaj-be694ba2b7c34a02a2f740354fc386fa2020-11-25T02:39:36ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402020-02-011110.3389/fpsyt.2020.00013497491Striatum-Mediated Deficits in Stimulus-Response Learning and Decision-Making in OCDNole M. Hiebert0Nole M. Hiebert1Nole M. Hiebert2Marc R. Lawrence3Hooman Ganjavi4Mark Watling5Adrian M. Owen6Adrian M. Owen7Adrian M. Owen8Ken N. Seergobin9Penny A. MacDonald10Penny A. MacDonald11Penny A. MacDonald12Penny A. MacDonald13Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, CanadaBrain and Mind Institute, University of Western Ontario, London, ON, CanadaDepartment of Physiology and Pharmacology, University of Western Ontario, London, ON, CanadaDepartment of Physiology and Pharmacology, University of Western Ontario, London, ON, CanadaDepartment of Psychiatry, University of Western Ontario, London, ON, CanadaDepartment of Psychiatry, University of Western Ontario, London, ON, CanadaBrain and Mind Institute, University of Western Ontario, London, ON, CanadaDepartment of Physiology and Pharmacology, University of Western Ontario, London, ON, CanadaDepartment of Psychology, University of Western Ontario, London, ON, CanadaBrain and Mind Institute, University of Western Ontario, London, ON, CanadaBrain and Mind Institute, University of Western Ontario, London, ON, CanadaDepartment of Physiology and Pharmacology, University of Western Ontario, London, ON, CanadaDepartment of Psychology, University of Western Ontario, London, ON, CanadaDepartment of Clinical Neurological Sciences, University of Western Ontario, London, ON, CanadaObsessive compulsive disorder (OCD) is a prevalent psychiatric disorder characterized by obsessions and compulsions. Studies investigating symptomatology and cognitive deficits in OCD frequently implicate the striatum. The aim of this study was to explore striatum-mediated cognitive deficits in patients with OCD as they complete a stimulus-response learning task previously shown to differentially rely on the dorsal (DS) and ventral striatum (VS). We hypothesized that patients with OCD will show both impaired decision-making and learning, coupled with reduced task-relevant activity in DS and VS, respectively, compared to healthy controls. We found that patients with OCD (n = 14) exhibited decision-making deficits and learned associations slower compared to healthy age-matched controls (n = 16). Along with these behavioral deficits, OCD patients had reduced task-relevant activity in DS and VS, compared to controls. This study reveals that responses in DS and VS are altered in OCD, and sheds light on the cognitive deficits and symptoms experienced by patients with OCD.https://www.frontiersin.org/article/10.3389/fpsyt.2020.00013/fullobsessive compulsive disorderneuroimagingstriatumlearningdecision-making |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Nole M. Hiebert Nole M. Hiebert Nole M. Hiebert Marc R. Lawrence Hooman Ganjavi Mark Watling Adrian M. Owen Adrian M. Owen Adrian M. Owen Ken N. Seergobin Penny A. MacDonald Penny A. MacDonald Penny A. MacDonald Penny A. MacDonald |
| spellingShingle |
Nole M. Hiebert Nole M. Hiebert Nole M. Hiebert Marc R. Lawrence Hooman Ganjavi Mark Watling Adrian M. Owen Adrian M. Owen Adrian M. Owen Ken N. Seergobin Penny A. MacDonald Penny A. MacDonald Penny A. MacDonald Penny A. MacDonald Striatum-Mediated Deficits in Stimulus-Response Learning and Decision-Making in OCD Frontiers in Psychiatry obsessive compulsive disorder neuroimaging striatum learning decision-making |
| author_facet |
Nole M. Hiebert Nole M. Hiebert Nole M. Hiebert Marc R. Lawrence Hooman Ganjavi Mark Watling Adrian M. Owen Adrian M. Owen Adrian M. Owen Ken N. Seergobin Penny A. MacDonald Penny A. MacDonald Penny A. MacDonald Penny A. MacDonald |
| author_sort |
Nole M. Hiebert |
| title |
Striatum-Mediated Deficits in Stimulus-Response Learning and Decision-Making in OCD |
| title_short |
Striatum-Mediated Deficits in Stimulus-Response Learning and Decision-Making in OCD |
| title_full |
Striatum-Mediated Deficits in Stimulus-Response Learning and Decision-Making in OCD |
| title_fullStr |
Striatum-Mediated Deficits in Stimulus-Response Learning and Decision-Making in OCD |
| title_full_unstemmed |
Striatum-Mediated Deficits in Stimulus-Response Learning and Decision-Making in OCD |
| title_sort |
striatum-mediated deficits in stimulus-response learning and decision-making in ocd |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Psychiatry |
| issn |
1664-0640 |
| publishDate |
2020-02-01 |
| description |
Obsessive compulsive disorder (OCD) is a prevalent psychiatric disorder characterized by obsessions and compulsions. Studies investigating symptomatology and cognitive deficits in OCD frequently implicate the striatum. The aim of this study was to explore striatum-mediated cognitive deficits in patients with OCD as they complete a stimulus-response learning task previously shown to differentially rely on the dorsal (DS) and ventral striatum (VS). We hypothesized that patients with OCD will show both impaired decision-making and learning, coupled with reduced task-relevant activity in DS and VS, respectively, compared to healthy controls. We found that patients with OCD (n = 14) exhibited decision-making deficits and learned associations slower compared to healthy age-matched controls (n = 16). Along with these behavioral deficits, OCD patients had reduced task-relevant activity in DS and VS, compared to controls. This study reveals that responses in DS and VS are altered in OCD, and sheds light on the cognitive deficits and symptoms experienced by patients with OCD. |
| topic |
obsessive compulsive disorder neuroimaging striatum learning decision-making |
| url |
https://www.frontiersin.org/article/10.3389/fpsyt.2020.00013/full |
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