Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

Exchange of extracellular cystine for intracellular glutamate by the antiporter system xc− is implicated in numerous pathologies. Pharmacological agents that inhibit system xc− activity with high potency have long been sought, but have remained elusive. In this study, we report that the small molecu...

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Bibliographic Details
Main Authors: Scott J Dixon, Darpan N Patel, Matthew Welsch, Rachid Skouta, Eric D Lee, Miki Hayano, Ajit G Thomas, Caroline E Gleason, Nicholas P Tatonetti, Barbara S Slusher, Brent R Stockwell
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-05-01
Series:eLife
Subjects:
reactive oxygen species
cell death
SLC7A11
cystine
sorafenib
erastin
Online Access:https://elifesciences.org/articles/02523

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