The effect of vitamin D on clinical outcomes in tuberculosis
Introduction: Vitamin D enhances immune responses to tubercle bacillus. The aim of our study is to determine the improvements of clinical outcome in patients taking cholecalciferol as supplement accompany anti-tuberculosis treatment. Materials and methods: In a placebo-controlled and double blinded...
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doaj-be87a5c7197947079b9a44e2ddce46822020-11-25T00:16:11ZengWolters Kluwer Medknow PublicationsEgyptian Journal of Chest Disease and Tuberculosis0422-76382017-07-0166341942310.1016/j.ejcdt.2017.01.004The effect of vitamin D on clinical outcomes in tuberculosisAliasghar Farazi0Farshideh Didgar1Aghmorad Sarafraz2Traditional and Complementary Medicine Research Center (TCMRC), Infectious Diseases Research Center (IDRC), Department of Infectious Diseases, School of Medicine, Arak University of Medical Sciences, Arak, IranInfectious Diseases Research Center (IDRC), Department of Infectious Diseases, School of Medicine, Arak University of Medical Sciences, Arak, IranSchool of Medicine, Arak University of Medical Sciences, Arak, IranIntroduction: Vitamin D enhances immune responses to tubercle bacillus. The aim of our study is to determine the improvements of clinical outcome in patients taking cholecalciferol as supplement accompany anti-tuberculosis treatment. Materials and methods: In a placebo-controlled and double blinded clinical trial sixty patients with pulmonary tuberculosis from March 2014 to July 2015 in Markazi province of Iran were randomized to take either single dose of 450,000 International Units of cholecalciferol or placebo. Evaluation was carried out at one, two and three months later. The first outcome was reduction in TB score and the secondary outcome was smear conversion and improvement of quality of life. Results: Mean calcidiol levels for the whole study population were 22.81 ± 10.76 ng/ml and there have been no associations between baseline calcidiol levels and sputum smear burden (P-value = 0.54). There was an association of TB severity score with lower levels of Vitamin D (P-value = 0.043). The Short Form (SF)-12 health survey scoring at enrolment in two arms did not differ significantly (P-value = 0.786). Two months’ later findings indicate that Vitamin D treatment had a positive effect on progressing health-related quality of life (P-value = 0.019) in each subscale of physical health score (P-value = 0.028) and mental health score (P-value = 0.025). Conclusions: Our findings indicated that single dose cholecalciferol supplementation can lead to improving clinical outcome in tuberculous patients especially in those with calcidiol deficiency and improve the health-related quality of life of TB patients.http://www.sciencedirect.com/science/article/pii/S0422763816302333CholecalciferolClinical outcomeQuality of lifeTuberculosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aliasghar Farazi Farshideh Didgar Aghmorad Sarafraz |
spellingShingle |
Aliasghar Farazi Farshideh Didgar Aghmorad Sarafraz The effect of vitamin D on clinical outcomes in tuberculosis Egyptian Journal of Chest Disease and Tuberculosis Cholecalciferol Clinical outcome Quality of life Tuberculosis |
author_facet |
Aliasghar Farazi Farshideh Didgar Aghmorad Sarafraz |
author_sort |
Aliasghar Farazi |
title |
The effect of vitamin D on clinical outcomes in tuberculosis |
title_short |
The effect of vitamin D on clinical outcomes in tuberculosis |
title_full |
The effect of vitamin D on clinical outcomes in tuberculosis |
title_fullStr |
The effect of vitamin D on clinical outcomes in tuberculosis |
title_full_unstemmed |
The effect of vitamin D on clinical outcomes in tuberculosis |
title_sort |
effect of vitamin d on clinical outcomes in tuberculosis |
publisher |
Wolters Kluwer Medknow Publications |
series |
Egyptian Journal of Chest Disease and Tuberculosis |
issn |
0422-7638 |
publishDate |
2017-07-01 |
description |
Introduction: Vitamin D enhances immune responses to tubercle bacillus. The aim of our study is to determine the improvements of clinical outcome in patients taking cholecalciferol as supplement accompany anti-tuberculosis treatment.
Materials and methods: In a placebo-controlled and double blinded clinical trial sixty patients with pulmonary tuberculosis from March 2014 to July 2015 in Markazi province of Iran were randomized to take either single dose of 450,000 International Units of cholecalciferol or placebo. Evaluation was carried out at one, two and three months later. The first outcome was reduction in TB score and the secondary outcome was smear conversion and improvement of quality of life.
Results: Mean calcidiol levels for the whole study population were 22.81 ± 10.76 ng/ml and there have been no associations between baseline calcidiol levels and sputum smear burden (P-value = 0.54). There was an association of TB severity score with lower levels of Vitamin D (P-value = 0.043). The Short Form (SF)-12 health survey scoring at enrolment in two arms did not differ significantly (P-value = 0.786). Two months’ later findings indicate that Vitamin D treatment had a positive effect on progressing health-related quality of life (P-value = 0.019) in each subscale of physical health score (P-value = 0.028) and mental health score (P-value = 0.025).
Conclusions: Our findings indicated that single dose cholecalciferol supplementation can lead to improving clinical outcome in tuberculous patients especially in those with calcidiol deficiency and improve the health-related quality of life of TB patients. |
topic |
Cholecalciferol Clinical outcome Quality of life Tuberculosis |
url |
http://www.sciencedirect.com/science/article/pii/S0422763816302333 |
work_keys_str_mv |
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