Lateral Inhibition in the Vertebrate Retina: The Case of the Missing Neurotransmitter.

Lateral Inhibition in the Vertebrate Retina: The Case of the Missing Neurotransmitter.

Lateral inhibition at the first synapse in the retina is important for visual perception, enhancing image contrast, color discrimination, and light adaptation. Despite decades of research, the feedback signal from horizontal cells to photoreceptors that generates lateral inhibition remains uncertain...

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Main Authors: Richard H Kramer, Christopher M Davenport
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-12-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC4675548?pdf=render
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spelling doaj-be89738fb8664c8e8c78a0faa126d5762021-07-02T13:59:43ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852015-12-011312e100232210.1371/journal.pbio.1002322Lateral Inhibition in the Vertebrate Retina: The Case of the Missing Neurotransmitter.Richard H KramerChristopher M DavenportLateral inhibition at the first synapse in the retina is important for visual perception, enhancing image contrast, color discrimination, and light adaptation. Despite decades of research, the feedback signal from horizontal cells to photoreceptors that generates lateral inhibition remains uncertain. GABA, protons, or an ephaptic mechanism have all been suggested as the primary mediator of feedback. However, the complexity of the reciprocal cone to horizontal cell synapse has left the identity of the feedback signal an unsolved mystery.http://europepmc.org/articles/PMC4675548?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Richard H Kramer
Christopher M Davenport
spellingShingle Richard H Kramer
Christopher M Davenport
Lateral Inhibition in the Vertebrate Retina: The Case of the Missing Neurotransmitter.
PLoS Biology
author_facet Richard H Kramer
Christopher M Davenport
author_sort Richard H Kramer
title Lateral Inhibition in the Vertebrate Retina: The Case of the Missing Neurotransmitter.
title_short Lateral Inhibition in the Vertebrate Retina: The Case of the Missing Neurotransmitter.
title_full Lateral Inhibition in the Vertebrate Retina: The Case of the Missing Neurotransmitter.
title_fullStr Lateral Inhibition in the Vertebrate Retina: The Case of the Missing Neurotransmitter.
title_full_unstemmed Lateral Inhibition in the Vertebrate Retina: The Case of the Missing Neurotransmitter.
title_sort lateral inhibition in the vertebrate retina: the case of the missing neurotransmitter.
publisher Public Library of Science (PLoS)
series PLoS Biology
issn 1544-9173
1545-7885
publishDate 2015-12-01
description Lateral inhibition at the first synapse in the retina is important for visual perception, enhancing image contrast, color discrimination, and light adaptation. Despite decades of research, the feedback signal from horizontal cells to photoreceptors that generates lateral inhibition remains uncertain. GABA, protons, or an ephaptic mechanism have all been suggested as the primary mediator of feedback. However, the complexity of the reciprocal cone to horizontal cell synapse has left the identity of the feedback signal an unsolved mystery.
url http://europepmc.org/articles/PMC4675548?pdf=render
work_keys_str_mv AT richardhkramer lateralinhibitioninthevertebrateretinathecaseofthemissingneurotransmitter
AT christophermdavenport lateralinhibitioninthevertebrateretinathecaseofthemissingneurotransmitter
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