Molecular rheotaxis directs DNA migration and concentration against a pressure-driven flow

Molecular rheotaxis directs DNA migration and concentration against a pressure-driven flow

Implementing a nucleic acid preconcentration method can improve the sensitivity of microfluidic analysis systems. Here Friedrich et al. concentrate DNA by many orders of magnitude using pressure-driven flow, which could lead to a simple and practical microanalysis platform.

Bibliographic Details
Main Authors: Sarah M. Friedrich, Jeffrey M. Burke, Kelvin J. Liu, Cornelius F. Ivory, Tza-Huei Wang
Format: Article
Language:English
Published: Nature Publishing Group 2017-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01214-y
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spelling doaj-be96a85d1e7e4c87a20d2f0eaaddda442021-05-11T07:46:16ZengNature Publishing GroupNature Communications2041-17232017-10-018111010.1038/s41467-017-01214-yMolecular rheotaxis directs DNA migration and concentration against a pressure-driven flowSarah M. Friedrich0Jeffrey M. Burke1Kelvin J. Liu2Cornelius F. Ivory3Tza-Huei Wang4Biomedical Engineering Department, Johns Hopkins UniversityCirculomics, Inc.Circulomics, Inc.Gene and Linda Voiland School of Chemical Engineering and Bioengineering, Washington State UniversityBiomedical Engineering Department, Johns Hopkins UniversityImplementing a nucleic acid preconcentration method can improve the sensitivity of microfluidic analysis systems. Here Friedrich et al. concentrate DNA by many orders of magnitude using pressure-driven flow, which could lead to a simple and practical microanalysis platform.https://doi.org/10.1038/s41467-017-01214-y
collection DOAJ
language English
format Article
sources DOAJ
author Sarah M. Friedrich
Jeffrey M. Burke
Kelvin J. Liu
Cornelius F. Ivory
Tza-Huei Wang
spellingShingle Sarah M. Friedrich
Jeffrey M. Burke
Kelvin J. Liu
Cornelius F. Ivory
Tza-Huei Wang
Molecular rheotaxis directs DNA migration and concentration against a pressure-driven flow
Nature Communications
author_facet Sarah M. Friedrich
Jeffrey M. Burke
Kelvin J. Liu
Cornelius F. Ivory
Tza-Huei Wang
author_sort Sarah M. Friedrich
title Molecular rheotaxis directs DNA migration and concentration against a pressure-driven flow
title_short Molecular rheotaxis directs DNA migration and concentration against a pressure-driven flow
title_full Molecular rheotaxis directs DNA migration and concentration against a pressure-driven flow
title_fullStr Molecular rheotaxis directs DNA migration and concentration against a pressure-driven flow
title_full_unstemmed Molecular rheotaxis directs DNA migration and concentration against a pressure-driven flow
title_sort molecular rheotaxis directs dna migration and concentration against a pressure-driven flow
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-10-01
description Implementing a nucleic acid preconcentration method can improve the sensitivity of microfluidic analysis systems. Here Friedrich et al. concentrate DNA by many orders of magnitude using pressure-driven flow, which could lead to a simple and practical microanalysis platform.
url https://doi.org/10.1038/s41467-017-01214-y
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AT jeffreymburke molecularrheotaxisdirectsdnamigrationandconcentrationagainstapressuredrivenflow
AT kelvinjliu molecularrheotaxisdirectsdnamigrationandconcentrationagainstapressuredrivenflow
AT corneliusfivory molecularrheotaxisdirectsdnamigrationandconcentrationagainstapressuredrivenflow
AT tzahueiwang molecularrheotaxisdirectsdnamigrationandconcentrationagainstapressuredrivenflow
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