C/EBPɑ is crucial determinant of epithelial maintenance by preventing epithelial-to-mesenchymal transition
In breast cancer TGF-β regulates C/EBPα and can induce epithelial-to-mesenchymal transition (EMT). Here, the authors show that C/EBPα maintains epithelial homeostasis and prevents EMT-mediated tumorigenesis.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2020-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-14556-x |
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doaj-beb8ddfc0b0b4b249f1fbb7841a7699b |
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Article |
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doaj-beb8ddfc0b0b4b249f1fbb7841a7699b2021-05-11T08:56:09ZengNature Publishing GroupNature Communications2041-17232020-02-0111111810.1038/s41467-020-14556-xC/EBPɑ is crucial determinant of epithelial maintenance by preventing epithelial-to-mesenchymal transitionAna Rita Lourenço0M. Guy Roukens1Danielle Seinstra2Cynthia L. Frederiks3Cornelieke E. Pals4Stephin J. Vervoort5Andreia S. Margarido6Jacco van Rheenen7Paul J. Coffer8Center for Molecular Medicine, University Medical Center UtrechtCenter for Molecular Medicine, University Medical Center UtrechtDepartment of Molecular Pathology, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121Center for Molecular Medicine, University Medical Center UtrechtCenter for Molecular Medicine, University Medical Center UtrechtCenter for Molecular Medicine, University Medical Center UtrechtDepartment of Molecular Pathology, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121Department of Molecular Pathology, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121Center for Molecular Medicine, University Medical Center UtrechtIn breast cancer TGF-β regulates C/EBPα and can induce epithelial-to-mesenchymal transition (EMT). Here, the authors show that C/EBPα maintains epithelial homeostasis and prevents EMT-mediated tumorigenesis.https://doi.org/10.1038/s41467-020-14556-x |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Ana Rita Lourenço M. Guy Roukens Danielle Seinstra Cynthia L. Frederiks Cornelieke E. Pals Stephin J. Vervoort Andreia S. Margarido Jacco van Rheenen Paul J. Coffer |
| spellingShingle |
Ana Rita Lourenço M. Guy Roukens Danielle Seinstra Cynthia L. Frederiks Cornelieke E. Pals Stephin J. Vervoort Andreia S. Margarido Jacco van Rheenen Paul J. Coffer C/EBPɑ is crucial determinant of epithelial maintenance by preventing epithelial-to-mesenchymal transition Nature Communications |
| author_facet |
Ana Rita Lourenço M. Guy Roukens Danielle Seinstra Cynthia L. Frederiks Cornelieke E. Pals Stephin J. Vervoort Andreia S. Margarido Jacco van Rheenen Paul J. Coffer |
| author_sort |
Ana Rita Lourenço |
| title |
C/EBPɑ is crucial determinant of epithelial maintenance by preventing epithelial-to-mesenchymal transition |
| title_short |
C/EBPɑ is crucial determinant of epithelial maintenance by preventing epithelial-to-mesenchymal transition |
| title_full |
C/EBPɑ is crucial determinant of epithelial maintenance by preventing epithelial-to-mesenchymal transition |
| title_fullStr |
C/EBPɑ is crucial determinant of epithelial maintenance by preventing epithelial-to-mesenchymal transition |
| title_full_unstemmed |
C/EBPɑ is crucial determinant of epithelial maintenance by preventing epithelial-to-mesenchymal transition |
| title_sort |
c/ebpɑ is crucial determinant of epithelial maintenance by preventing epithelial-to-mesenchymal transition |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-02-01 |
| description |
In breast cancer TGF-β regulates C/EBPα and can induce epithelial-to-mesenchymal transition (EMT). Here, the authors show that C/EBPα maintains epithelial homeostasis and prevents EMT-mediated tumorigenesis. |
| url |
https://doi.org/10.1038/s41467-020-14556-x |
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