Frontal non-invasive neurostimulation modulates antisaccade preparation in non-human primates.
A combination of oculometric measurements, invasive electrophysiological recordings and microstimulation have proven instrumental to study the role of the Frontal Eye Field (FEF) in saccadic activity. We hereby gauged the ability of a non-invasive neurostimulation technology, Transcranial Magnetic S...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3368878?pdf=render |
id |
doaj-bebe98ec492743dfa3eab45598d1519d |
---|---|
record_format |
Article |
spelling |
doaj-bebe98ec492743dfa3eab45598d1519d2020-11-24T20:49:54ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0176e3867410.1371/journal.pone.0038674Frontal non-invasive neurostimulation modulates antisaccade preparation in non-human primates.Antoni Valero-CabreNicolas WattiezMorgane MonfortChantal FrançoisSophie Rivaud-PéchouxBertrand GaymardPierre PougetA combination of oculometric measurements, invasive electrophysiological recordings and microstimulation have proven instrumental to study the role of the Frontal Eye Field (FEF) in saccadic activity. We hereby gauged the ability of a non-invasive neurostimulation technology, Transcranial Magnetic Stimulation (TMS), to causally interfere with frontal activity in two macaque rhesus monkeys trained to perform a saccadic antisaccade task. We show that online single pulse TMS significantly modulated antisaccade latencies. Such effects proved dependent on TMS site (effects on FEF but not on an actively stimulated control site), TMS modality (present under active but not sham TMS on the FEF area), TMS intensity (intensities of at least 40% of the TMS machine maximal output required), TMS timing (more robust for pulses delivered at 150 ms than at 100 post target onset) and visual hemifield (relative latency decreases mainly for ipsilateral AS). Our results demonstrate the feasibility of using TMS to causally modulate antisaccade-associated computations in the non-human primate brain and support the use of this approach in monkeys to study brain function and its non-invasive neuromodulation for exploratory and therapeutic purposes.http://europepmc.org/articles/PMC3368878?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Antoni Valero-Cabre Nicolas Wattiez Morgane Monfort Chantal François Sophie Rivaud-Péchoux Bertrand Gaymard Pierre Pouget |
spellingShingle |
Antoni Valero-Cabre Nicolas Wattiez Morgane Monfort Chantal François Sophie Rivaud-Péchoux Bertrand Gaymard Pierre Pouget Frontal non-invasive neurostimulation modulates antisaccade preparation in non-human primates. PLoS ONE |
author_facet |
Antoni Valero-Cabre Nicolas Wattiez Morgane Monfort Chantal François Sophie Rivaud-Péchoux Bertrand Gaymard Pierre Pouget |
author_sort |
Antoni Valero-Cabre |
title |
Frontal non-invasive neurostimulation modulates antisaccade preparation in non-human primates. |
title_short |
Frontal non-invasive neurostimulation modulates antisaccade preparation in non-human primates. |
title_full |
Frontal non-invasive neurostimulation modulates antisaccade preparation in non-human primates. |
title_fullStr |
Frontal non-invasive neurostimulation modulates antisaccade preparation in non-human primates. |
title_full_unstemmed |
Frontal non-invasive neurostimulation modulates antisaccade preparation in non-human primates. |
title_sort |
frontal non-invasive neurostimulation modulates antisaccade preparation in non-human primates. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2012-01-01 |
description |
A combination of oculometric measurements, invasive electrophysiological recordings and microstimulation have proven instrumental to study the role of the Frontal Eye Field (FEF) in saccadic activity. We hereby gauged the ability of a non-invasive neurostimulation technology, Transcranial Magnetic Stimulation (TMS), to causally interfere with frontal activity in two macaque rhesus monkeys trained to perform a saccadic antisaccade task. We show that online single pulse TMS significantly modulated antisaccade latencies. Such effects proved dependent on TMS site (effects on FEF but not on an actively stimulated control site), TMS modality (present under active but not sham TMS on the FEF area), TMS intensity (intensities of at least 40% of the TMS machine maximal output required), TMS timing (more robust for pulses delivered at 150 ms than at 100 post target onset) and visual hemifield (relative latency decreases mainly for ipsilateral AS). Our results demonstrate the feasibility of using TMS to causally modulate antisaccade-associated computations in the non-human primate brain and support the use of this approach in monkeys to study brain function and its non-invasive neuromodulation for exploratory and therapeutic purposes. |
url |
http://europepmc.org/articles/PMC3368878?pdf=render |
work_keys_str_mv |
AT antonivalerocabre frontalnoninvasiveneurostimulationmodulatesantisaccadepreparationinnonhumanprimates AT nicolaswattiez frontalnoninvasiveneurostimulationmodulatesantisaccadepreparationinnonhumanprimates AT morganemonfort frontalnoninvasiveneurostimulationmodulatesantisaccadepreparationinnonhumanprimates AT chantalfrancois frontalnoninvasiveneurostimulationmodulatesantisaccadepreparationinnonhumanprimates AT sophierivaudpechoux frontalnoninvasiveneurostimulationmodulatesantisaccadepreparationinnonhumanprimates AT bertrandgaymard frontalnoninvasiveneurostimulationmodulatesantisaccadepreparationinnonhumanprimates AT pierrepouget frontalnoninvasiveneurostimulationmodulatesantisaccadepreparationinnonhumanprimates |
_version_ |
1716805524658323456 |