A genome-wide homozygosity association study identifies runs of homozygosity associated with rheumatoid arthritis in the human major histocompatibility complex.
Rheumatoid arthritis (RA) is a chronic inflammatory disorder with a polygenic mode of inheritance. This study examined the hypothesis that runs of homozygosity (ROHs) play a recessive-acting role in the underlying RA genetic mechanism and identified RA-associated ROHs. Ours is the first genome-wide...
Main Authors: | Hsin-Chou Yang, Lun-Ching Chang, Yu-Jen Liang, Chien-Hsing Lin, Pei-Li Wang |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3335047?pdf=render |
Similar Items
-
Long runs of homozygosity are associated with Alzheimer’s disease
by: Sonia Moreno-Grau, et al.
Published: (2021-02-01) -
Association of rheumatoid arthritis according to the degree of genetic homozygosity and gender: Pilot study
by: Cvjetićanin Suzana, et al.
Published: (2019-01-01) -
Runs of homozygosity and population history in cattle
by: Purfield Deirdre C, et al.
Published: (2012-08-01) -
Genome-Wide Scan for Runs of Homozygosity Identifies Candidate Genes in Three Pig Breeds
by: Rui Xie, et al.
Published: (2019-08-01) -
Genome-Wide Assessment of Runs of Homozygosity in Chinese Wagyu Beef Cattle
by: Guoyao Zhao, et al.
Published: (2020-08-01)