SYNERGIC TRIAL (SYNchronizing Exercises, Remedies in Gait and Cognition) a multi-Centre randomized controlled double blind trial to improve gait and cognition in mild cognitive impairment
Abstract Background Physical exercise, cognitive training, and vitamin D are low cost interventions that have the potential to enhance cognitive function and mobility in older adults, especially in pre-dementia states such as Mild Cognitive Impairment (MCI). Aerobic and progressive resistance exerci...
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BMC
2018-04-01
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Series: | BMC Geriatrics |
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Online Access: | http://link.springer.com/article/10.1186/s12877-018-0782-7 |
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doaj-beeea0f39dac4e5d9cf47ac0aeabcd14 |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Manuel Montero-Odasso Quincy J. Almeida Amer M. Burhan Richard Camicioli Julien Doyon Sarah Fraser Karen Li Teresa Liu-Ambrose Laura Middleton Susan Muir-Hunter William McIlroy José A. Morais Frederico Pieruccini-Faria Kevin Shoemaker Mark Speechley Akshya Vasudev G. Y. Zou Nicolas Berryman Maxime Lussier Leanne Vanderhaeghe Louis Bherer |
spellingShingle |
Manuel Montero-Odasso Quincy J. Almeida Amer M. Burhan Richard Camicioli Julien Doyon Sarah Fraser Karen Li Teresa Liu-Ambrose Laura Middleton Susan Muir-Hunter William McIlroy José A. Morais Frederico Pieruccini-Faria Kevin Shoemaker Mark Speechley Akshya Vasudev G. Y. Zou Nicolas Berryman Maxime Lussier Leanne Vanderhaeghe Louis Bherer SYNERGIC TRIAL (SYNchronizing Exercises, Remedies in Gait and Cognition) a multi-Centre randomized controlled double blind trial to improve gait and cognition in mild cognitive impairment BMC Geriatrics MCI Exercise Cognitive training Vitamin D Cognition Gait |
author_facet |
Manuel Montero-Odasso Quincy J. Almeida Amer M. Burhan Richard Camicioli Julien Doyon Sarah Fraser Karen Li Teresa Liu-Ambrose Laura Middleton Susan Muir-Hunter William McIlroy José A. Morais Frederico Pieruccini-Faria Kevin Shoemaker Mark Speechley Akshya Vasudev G. Y. Zou Nicolas Berryman Maxime Lussier Leanne Vanderhaeghe Louis Bherer |
author_sort |
Manuel Montero-Odasso |
title |
SYNERGIC TRIAL (SYNchronizing Exercises, Remedies in Gait and Cognition) a multi-Centre randomized controlled double blind trial to improve gait and cognition in mild cognitive impairment |
title_short |
SYNERGIC TRIAL (SYNchronizing Exercises, Remedies in Gait and Cognition) a multi-Centre randomized controlled double blind trial to improve gait and cognition in mild cognitive impairment |
title_full |
SYNERGIC TRIAL (SYNchronizing Exercises, Remedies in Gait and Cognition) a multi-Centre randomized controlled double blind trial to improve gait and cognition in mild cognitive impairment |
title_fullStr |
SYNERGIC TRIAL (SYNchronizing Exercises, Remedies in Gait and Cognition) a multi-Centre randomized controlled double blind trial to improve gait and cognition in mild cognitive impairment |
title_full_unstemmed |
SYNERGIC TRIAL (SYNchronizing Exercises, Remedies in Gait and Cognition) a multi-Centre randomized controlled double blind trial to improve gait and cognition in mild cognitive impairment |
title_sort |
synergic trial (synchronizing exercises, remedies in gait and cognition) a multi-centre randomized controlled double blind trial to improve gait and cognition in mild cognitive impairment |
publisher |
BMC |
series |
BMC Geriatrics |
issn |
1471-2318 |
publishDate |
2018-04-01 |
description |
Abstract Background Physical exercise, cognitive training, and vitamin D are low cost interventions that have the potential to enhance cognitive function and mobility in older adults, especially in pre-dementia states such as Mild Cognitive Impairment (MCI). Aerobic and progressive resistance exercises have benefits to cognitive performance, though evidence is somewhat inconsistent. We postulate that combined aerobic exercise (AE) and progressive resistance training (RT) (combined exercise) will have a better effect on cognition than a balance and toning control (BAT) intervention in older adults with MCI. We also expect that adding cognitive training and vitamin D supplementation to the combined exercise, as a multimodal intervention, will have synergistic efficacy. Methods The SYNERGIC trial (SYNchronizing Exercises, Remedies in GaIt and Cognition) is a multi-site, double-blinded, five-arm, controlled trial that assesses the potential synergic effect of combined AE and RT on cognition and mobility, with and without cognitive training and vitamin D supplementation in older adults with MCI. Two-hundred participants with MCI aged 60 to 85 years old will be randomized to one of five arms, four of which include combined exercise plus combinations of dual-task cognitive training (real vs. sham) and vitamin D supplementation (3 × 10,000 IU/wk. vs. placebo) in a quasi-factorial design, and one arm which receives all control interventions. The primary outcome measure is the ADAS-Cog (13 and plus modalities) measured at baseline and at 6 months of follow-up. Secondary outcomes include neuroimaging, neuro-cognitive performance, gait and mobility performance, and serum biomarkers of inflammation (C reactive protein and interleukin 6), neuroplasticity (brain-derived neurotropic factor), endothelial markers (vascular endothelial growth factor 1), and vitamin D serum levels. Discussion The SYNERGIC Trial will establish the efficacy and feasibility of a multimodal intervention to improve cognitive performance and mobility outcomes in MCI. These interventions may contribute to new approaches to stabilize and reverse cognitive-mobility decline in older individuals with MCI. Trial Registration Identifier: NCT02808676. https://www.clinicaltrials.gov/ct2/show/NCT02808676. |
topic |
MCI Exercise Cognitive training Vitamin D Cognition Gait |
url |
http://link.springer.com/article/10.1186/s12877-018-0782-7 |
work_keys_str_mv |
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doaj-beeea0f39dac4e5d9cf47ac0aeabcd142020-11-25T03:56:49ZengBMCBMC Geriatrics1471-23182018-04-0118111510.1186/s12877-018-0782-7SYNERGIC TRIAL (SYNchronizing Exercises, Remedies in Gait and Cognition) a multi-Centre randomized controlled double blind trial to improve gait and cognition in mild cognitive impairmentManuel Montero-Odasso0Quincy J. Almeida1Amer M. Burhan2Richard Camicioli3Julien Doyon4Sarah Fraser5Karen Li6Teresa Liu-Ambrose7Laura Middleton8Susan Muir-Hunter9William McIlroy10José A. Morais11Frederico Pieruccini-Faria12Kevin Shoemaker13Mark Speechley14Akshya Vasudev15G. Y. Zou16Nicolas Berryman17Maxime Lussier18Leanne Vanderhaeghe19Louis Bherer20Department of Medicine, Division of Geriatric Medicine, Schulich School of Medicine & Dentistry, University of Western OntarioSun Life Financial Movement Disorders Research Centre, Wilfrid Laurier UniversitySchulich School of Medicine and Dentistry, University of Western OntarioGeriatric and Cognitive Neurology, University of AlbertaFunctional Neuroimaging Unit, University of MontrealDepartment of Psychology-University of OttawaDepartment of Psychology and PERFORM Centre, Concordia UniversityDepartment of Physical Therapy, University of British Columbia, Centre for Hip Health and Mobility, and Djavad Mowafaghian Centre for Brain Health, Vancouver Coastal Research Institute, University of British ColumbiaDepartment of Kinesiology, University of WaterlooSchool of Physical Therapy, University of Western OntarioDivision of Neurology and Department of Medicine, University of Toronto. Tanz Centre for Research in Neurodegenerative Diseases, University of TorontoDivision of Geriatrics and Centre of Excellence in Aging and Chronic Disease, McGill UniversityDepartment of Medicine, Division of Geriatric Medicine, Schulich School of Medicine & Dentistry, University of Western OntarioDepartment of Kinesiology, University of Western OntarioDepartment of Epidemiology and Biostatistics, Schulich School of Medicine & Dentistry, University of Western OntarioDepartment of Psychiatry, Division of Geriatric Psychiatry and Department of Medicine, Division of Clinical Pharmacology, University of Western OntarioDepartment of Epidemiology and Biostatistics, Schulich School of Medicine & Dentistry, University of Western OntarioCentre de Recherche, Institut Universitaire de Gériatrie de MontréalCentre de Recherche, Institut Universitaire de Gériatrie de MontréalSt. Joseph’s Health CareDepartment of Psychology and PERFORM Centre, Concordia UniversityAbstract Background Physical exercise, cognitive training, and vitamin D are low cost interventions that have the potential to enhance cognitive function and mobility in older adults, especially in pre-dementia states such as Mild Cognitive Impairment (MCI). Aerobic and progressive resistance exercises have benefits to cognitive performance, though evidence is somewhat inconsistent. We postulate that combined aerobic exercise (AE) and progressive resistance training (RT) (combined exercise) will have a better effect on cognition than a balance and toning control (BAT) intervention in older adults with MCI. We also expect that adding cognitive training and vitamin D supplementation to the combined exercise, as a multimodal intervention, will have synergistic efficacy. Methods The SYNERGIC trial (SYNchronizing Exercises, Remedies in GaIt and Cognition) is a multi-site, double-blinded, five-arm, controlled trial that assesses the potential synergic effect of combined AE and RT on cognition and mobility, with and without cognitive training and vitamin D supplementation in older adults with MCI. Two-hundred participants with MCI aged 60 to 85 years old will be randomized to one of five arms, four of which include combined exercise plus combinations of dual-task cognitive training (real vs. sham) and vitamin D supplementation (3 × 10,000 IU/wk. vs. placebo) in a quasi-factorial design, and one arm which receives all control interventions. The primary outcome measure is the ADAS-Cog (13 and plus modalities) measured at baseline and at 6 months of follow-up. Secondary outcomes include neuroimaging, neuro-cognitive performance, gait and mobility performance, and serum biomarkers of inflammation (C reactive protein and interleukin 6), neuroplasticity (brain-derived neurotropic factor), endothelial markers (vascular endothelial growth factor 1), and vitamin D serum levels. Discussion The SYNERGIC Trial will establish the efficacy and feasibility of a multimodal intervention to improve cognitive performance and mobility outcomes in MCI. These interventions may contribute to new approaches to stabilize and reverse cognitive-mobility decline in older individuals with MCI. Trial Registration Identifier: NCT02808676. https://www.clinicaltrials.gov/ct2/show/NCT02808676.http://link.springer.com/article/10.1186/s12877-018-0782-7MCIExerciseCognitive trainingVitamin DCognitionGait |